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Potential bias caused by control selection in secondary data analysis: Nonaspirin nonsteroidal anti-inflammatory drugs and hemorrhagic stroke

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dc.contributor.authorChoi, Nam-Kyong-
dc.contributor.authorHahn, Seokyung-
dc.contributor.authorYoon, Byung-Woo-
dc.contributor.authorPark, Byung-Joo-
dc.date.accessioned2012-06-08T01:14:37Z-
dc.date.available2012-06-08T01:14:37Z-
dc.date.issued2010-06-
dc.identifier.citationPHARMACOEPIDEMIOLOGY AND DRUG SAFETY; Vol.19 6; 604-609ko_KR
dc.identifier.issn1053-8569-
dc.identifier.urihttp://hdl.handle.net/10371/76906-
dc.description.abstractBackground This study investigated the potential for bias introduction when selecting controls for secondary analysis of case-control study data. Methods We used a data set previously collected for an acute brain bleeding analysis (ABBA) study, which was designed to investigate the risk of hemorrhagic stroke (HS) resulting from the use of phenylpropanolamine in Korea. Cases in that study had experienced an HS. Each HS case was matched with age- and gender-based hospital and community controls. Information was obtained on drug exposures including nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs). Odds ratios (OR) for, and 95% confidence intervals (CI) of, experiencing an HS were calculated using conditional logistic regressions for each control group. Results A total of 940 patients were matched with 1880 controls. The OR of HS occurring in NANSAID users was 1.18 (95%CI, 0.80-1.73) in community controls and 0.67 (95%CI, 0.45-0.98) in hospital controls. The majority of the hospital controls were selected from patients who had visited neurology, neurosurgery, or orthopedic departments. Conclusion The difference between OR values estimated from hospital and community controls could be the result of selection bias. The study data were originally obtained for a different purpose than this study, and NANSAID use was not considered when the hospital controls were selected. When performing secondary analyses, extra care is needed to note whether the results are consistent across control groups and whether there are indications of bias related to the selection of those controls. Copyright (C) 2010 John Wiley & Sons, Ltd.ko_KR
dc.language.isoenko_KR
dc.publisherJOHN WILEY & SONS LTDko_KR
dc.subjectselection biasko_KR
dc.subjectsecondary data analysisko_KR
dc.subjectnonsteroidalko_KR
dc.subjectcase-control studiesko_KR
dc.subjecthemorrhagicko_KR
dc.subjectstrokeko_KR
dc.subjectanti-inflammatory agentsko_KR
dc.titlePotential bias caused by control selection in secondary data analysis: Nonaspirin nonsteroidal anti-inflammatory drugs and hemorrhagic strokeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최남경-
dc.contributor.AlternativeAuthor한서경-
dc.contributor.AlternativeAuthor윤병우-
dc.contributor.AlternativeAuthor박병주-
dc.identifier.doi10.1002/pds.1903-
dc.citation.journaltitlePHARMACOEPIDEMIOLOGY AND DRUG SAFETY-
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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