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Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight

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dc.contributor.authorLee, Bo-Eun-
dc.contributor.authorHong, Yun-Chul-
dc.contributor.authorPark, Hyesook-
dc.contributor.authorHa, Mina-
dc.contributor.authorChang, Namsoo-
dc.contributor.authorKim, Boong-Nyun-
dc.contributor.authorKim, Byung-Mi-
dc.contributor.authorHa, Eun-Hee-
dc.contributor.authorJo, Seong-Joon-
dc.contributor.authorKim, Young-Ju-
dc.contributor.authorRoh, Young-Man-
dc.contributor.authorKoo, Bon Sang-
dc.date.accessioned2012-06-08T06:31:57Z-
dc.date.available2012-06-08T06:31:57Z-
dc.date.issued2010-03-
dc.identifier.citationENVIRONMENTAL HEALTH PERSPECTIVES; Vol.118 3; 437-443ko_KR
dc.identifier.issn0091-6765-
dc.identifier.urihttp://hdl.handle.net/10371/76908-
dc.description.abstractBACKGROUND: Mercury (Hg) is toxic to both the reproductive and nervous systems. In addition, glutathione S-transferases (GSTs), which conjugate glutathione to a variety of electrophilic compounds, are involved in the detoxification of Hg. OBJECTIVE: In this study we examined the association between prenatal exposure to Hg and birth weight as well as the influence of GST polymorphisms. METHODS: The total Hg concentration in maternal and cord blood was measured from 417 Korean women and newborns in the Mothers and Children`s Environmental Health study from 2006 to 2008. Information on birth weight was collected from the patients` medical records. The genotyping of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms was carried out using polymerase chain reaction. Regression analysis was performed to determine the association between the blood Hg concentration and birth weight in mothers with GSTM1 and GSTT1 polymorphisms. RESULTS: The geometric mean levels of Hg in the maternal blood during late pregnancy and in cord blood were 3.30 mu g/L and 5.53 mu g/L, respectively. For mothers with the GSTT1 null genotype, elevated Hg levels in maternal blood during late pregnancy were associated with an increased risk of lower birth weight. For mothers with both GSTM1 and GSTT1 null genotype, both maternal and cord blood Hg levels were associated with lower birth weight. CONCLUSIONS: This study suggests that the interactions of Hg with GSTM1 and GSTT1 polymorphisms play a role in reducing birth weight.ko_KR
dc.language.isoenko_KR
dc.publisherUS DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCEko_KR
dc.subjectbirth weightko_KR
dc.subjectGSTT1ko_KR
dc.subjectGSTM1ko_KR
dc.subjectmercuryko_KR
dc.subjectpregnancyko_KR
dc.subjectpolymorphismko_KR
dc.titleInteraction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weightko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이보은-
dc.contributor.AlternativeAuthor홍윤철-
dc.contributor.AlternativeAuthor박혜숙-
dc.contributor.AlternativeAuthor하미나-
dc.contributor.AlternativeAuthor구본상-
dc.contributor.AlternativeAuthor장남수-
dc.contributor.AlternativeAuthor노영만-
dc.contributor.AlternativeAuthor김병연-
dc.contributor.AlternativeAuthor김영주-
dc.contributor.AlternativeAuthor김병미-
dc.contributor.AlternativeAuthor조성준-
dc.contributor.AlternativeAuthor하은희-
dc.identifier.doi10.1289/ehp.0900731-
dc.citation.journaltitleENVIRONMENTAL HEALTH PERSPECTIVES-
dc.description.citedreferenceENGSTROM K, 2008, GENETIC VARIATION GL-
dc.description.citedreferenceDaniels JL, 2007, PAEDIATR PERINAT EP, V21, P448-
dc.description.citedreferenceBeyrouty P, 2006, NEUROTOXICOL TERATOL, V28, P49, DOI 10.1016/j.ntt.2005.11.002-
dc.description.citedreferenceCustodio HM, 2005, ARCH ENVIRON HEALTH, V60, P17-
dc.description.citedreferenceCustodio HM, 2004, ARCH ENVIRON HEALTH, V59, P588-
dc.description.citedreferenceCounter SA, 2004, TOXICOL APPL PHARM, V198, P209, DOI 10.1016/j.taap.2003.11.032-
dc.description.citedreferenceCASANUEVA E, 2003, J NUTR, V133, P1700-
dc.description.citedreferenceBallatori N, 2002, ENVIRON HEALTH PERSP, V110, P689-
dc.description.citedreferenceDusinska M, 2001, MUTAT RES-FUND MOL M, V482, P47, DOI 10.1016/S0027-5107(01)00209-3-
dc.description.citedreferenceCastoldi AF, 2001, BRAIN RES BULL, V55, P197-
dc.description.citedreferenceBjerregaard P, 2000, SCI TOTAL ENVIRON, V245, P195, DOI 10.1016/S0048-9697(99)00444-1-
dc.description.citedreferenceChen CY, 1998, J TOXICOL ENV HEAL A, V54, P37-
dc.description.citedreferenceClarkson TW, 1997, CRIT REV CL LAB SCI, V34, P369-
dc.description.citedreferenceCLARKSON TW, 1993, ENVIRON HEALTH PERSP, V100, P31-
dc.description.citedreferenceBALLATORI N, 1985, FUND APPL TOXICOL, V5, P816-
dc.description.citedreferenceBRODSKY JB, 1985, J AM DENT ASSOC, V111, P779-
dc.description.tc5-
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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