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Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study
Cited 14 time in
Web of Science
Cited 17 time in Scopus
- Authors
- Issue Date
- 2009-07
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- BRITISH JOURNAL OF CANCER; Vol.101 3; 526-529
- Keywords
- stomach neoplasms ; Epstein-Barr virus ; Korea ; nested case-control study
- Abstract
- BACKGROUND: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer. METHODS: Among 14 440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs). RESULTS: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51-1.46) were not associated with gastric cancer risk. CONCLUSION: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.
- ISSN
- 0007-0920
- Language
- English
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