Browse

Immunomodulation of Delayed-Type Hypersensitivity Responses by Mesenchymal Stem Cells Is Associated with Bystander T Cell Apoptosis in the Draining Lymph Node

DC Field Value Language
dc.contributor.authorLim, Jong-Hyung-
dc.contributor.authorKim, Jung-Sik-
dc.contributor.authorYoon, Il-Hee-
dc.contributor.authorShin, Jun-Seop-
dc.contributor.authorYang, Seung-Ha-
dc.contributor.authorPark, Chung-Gyu-
dc.contributor.authorKim, Sang-Joon-
dc.contributor.authorNam, Hye-Young-
dc.date.accessioned2012-06-11T01:59:46Z-
dc.date.available2012-06-11T01:59:46Z-
dc.date.issued2010-10-01-
dc.identifier.citationJOURNAL OF IMMUNOLOGY; Vol.185 7; 4022-4029ko_KR
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10371/76937-
dc.description.abstractDisease amelioration by mesenchymal stem cells (MSCs) has been shown to be closely related to their immunomodulatory functions on the host immune system in many disease models. However, the underlying mechanisms of how these cells affect the immune cells in vivo are not fully understood. In this study, we report findings that a small but significant number of MSCs accumulate in the secondary lymphoid organs and attenuate delayed-type hypersensitivity (DTH) response by inducing apoptotic cell death of surrounding immune cells in the draining lymph node (LN). In the migration study, i.v. infused GFP-MSCs preferentially accumulated at the boundary between the paracortical area and the germinal center in the LNs, in close proximity to various types of immune cells including T, B, and dendritic cells in a dose-dependent manner. As a result, accumulated MSCs markedly attenuated DTH response in proportion to the number of MSCs infused. During the DTH response, the infiltration of T cells in the challenged site was significantly decreased, whereas a number of apoptotic T cells were remarkably increased in the draining LN. Apoptosis was significantly induced in activated T cells (CD3(+) and BrdU(+)), but not in the resting T cells (CD3(+) and BrdU(+)). NO was associated with these apoptotic events. Taken together, we conclude that significant numbers of i.v. infused MSCs preferentially localize in the draining LN, where they induce apoptosis of the activated T cells by producing NO and thus attenuate the DTH response. The Journal of Immunology, 2010, 185: 4022-4029.ko_KR
dc.language.isoenko_KR
dc.publisherAMER ASSOC IMMUNOLOGISTSko_KR
dc.titleImmunomodulation of Delayed-Type Hypersensitivity Responses by Mesenchymal Stem Cells Is Associated with Bystander T Cell Apoptosis in the Draining Lymph Nodeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임종형-
dc.contributor.AlternativeAuthor김정식-
dc.contributor.AlternativeAuthor윤일희-
dc.contributor.AlternativeAuthor신준섭-
dc.contributor.AlternativeAuthor남혜영-
dc.contributor.AlternativeAuthor양승하-
dc.contributor.AlternativeAuthor김상준-
dc.contributor.AlternativeAuthor박청규-
dc.identifier.doi10.4049/jimmunol.0902723-
dc.citation.journaltitleJOURNAL OF IMMUNOLOGY-
dc.description.citedreferenceYang SH, 2009, EXP MOL MED, V41, P315, DOI 10.3858/emm.2009.41.5.035-
dc.description.citedreferenceNemeth K, 2009, NAT MED, V15, P42, DOI 10.1038/nm.1905-
dc.description.citedreferenceOhtaki H, 2008, P NATL ACAD SCI USA, V105, P14638, DOI 10.1073/pnas.0803670105-
dc.description.citedreferenceSasaki M, 2008, J IMMUNOL, V180, P2581-
dc.description.citedreferenceRen GW, 2008, CELL STEM CELL, V2, P141, DOI 10.1016/j.stem.2007.11.014-
dc.description.citedreferenceRaffaghello L, 2008, STEM CELLS, V26, P151, DOI 10.1634/stemcells.2007-0416-
dc.description.citedreferenceBenvenuto F, 2007, STEM CELLS, V25, P1753, DOI 10.1634/stemcells.2007-0068-
dc.description.citedreferenceXu GW, 2007, CELL RES, V17, P240, DOI 10.1038/cr.2007.4-
dc.description.citedreferenceGerdoni E, 2007, ANN NEUROL, V61, P219, DOI 10.1002/ana.21076-
dc.description.citedreferenceRamasamy R, 2007, TRANSPLANTATION, V83, P71, DOI 10.1097/01.tp.0000244572.24780.54-
dc.description.citedreferenceSato K, 2007, BLOOD, V109, P228, DOI 10.1182/blood-2006-02-002246-
dc.description.citedreferenceMouiseddine M, 2007, BRIT J RADIOL, V80, pS49, DOI 10.1259/bjr/25927054-
dc.description.citedreferenceSpaggiari GM, 2006, BLOOD, V107, P1484, DOI 10.1182/blood-2005-07-2775-
dc.description.citedreferenceCorcione A, 2006, BLOOD, V107, P367, DOI 10.1182/blood-2005-07-2657-
dc.description.citedreferenceZappia E, 2005, BLOOD, V106, P1755, DOI 10.1182/blood-2005-04-1496-
dc.description.citedreferencePlumas J, 2005, LEUKEMIA, V19, P1597, DOI 10.1038/sj.leu.2403871-
dc.description.citedreferenceVon Luttichau I, 2005, STEM CELLS DEV, V14, P329-
dc.description.citedreferenceDjouad F, 2005, ARTHRITIS RHEUM, V52, P1595, DOI 10.1002/art.21012-
dc.description.citedreferenceGlennie S, 2005, BLOOD, V105, P2821-
dc.description.citedreferenceAggarwal S, 2005, BLOOD, V105, P1815, DOI 10.1182/blood-2004-04-1559-
dc.description.citedreferenceMeisel R, 2004, BLOOD, V103, P4619, DOI 10.1182/blood-2003-11-3909-
dc.description.citedreferenceLe Blanc K, 2004, LANCET, V363, P1439-
dc.description.citedreferenceChapel A, 2003, J GENE MED, V5, P1028, DOI 10.1002/jgm.452-
dc.description.citedreferenceDevine SM, 2003, BLOOD, V101, P2999, DOI 10.1182/blood-2002-06-1830-
dc.description.citedreferenceDi Nicola M, 2002, BLOOD, V99, P3838-
dc.description.citedreferenceVarona R, 2001, J CLIN INVEST, V107, pR37-
dc.description.citedreferenceGao JZ, 2001, CELLS TISSUES ORGANS, V169, P12-
dc.description.citedreferenceWang BH, 2000, J IMMUNOL, V165, P6783-
dc.description.citedreferenceKoc ON, 2000, J CLIN ONCOL, V18, P307-
dc.description.citedreferenceKopen GC, 1999, P NATL ACAD SCI USA, V96, P10711-
dc.description.citedreferencePittenger MF, 1999, SCIENCE, V284, P143-
dc.description.citedreferencePereira RF, 1998, P NATL ACAD SCI USA, V95, P1142-
dc.description.citedreferenceGARRIGUE JL, 1994, CONTACT DERMATITIS, V30, P231-
dc.description.citedreferenceMALORNY U, 1990, INT ARCH ALLER A IMM, V92, P356-
dc.description.citedreferenceVADAS MA, 1975, INT ARCH ALLER A IMM, V49, P670-
dc.description.citedreferenceFRIEDENS.AJ, 1966, J EMBRYOL EXP MORPH, V16, P381-
dc.description.citedreferenceEISEN HN, 1952, J EXP MED, V95, P473-
dc.description.tc6-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Microbiology (미생물학전공)Journal Papers (저널논문_미생물학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse