Publications
Detailed Information
Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation
Cited 14 time in
Web of Science
Cited 15 time in Scopus
- Authors
- Issue Date
- 2009-04
- Publisher
- WILEY-BLACKWELL PUBLISHING, INC
- Citation
- VETERINARY OPHTHALMOLOGY; Vol.12 2; 78-82
- Keywords
- cornea ; full-thickness ; lamellar ; xenotransplantation ; penetrating
- Abstract
- To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig`s cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively (P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates (P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms.
- ISSN
- 1463-5216
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.