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Effects of Postnatal Age and Aminophylline on the Maturation of Amplitude-Integrated Electroencephalography Activity in Preterm Infants

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Lee, Hyun Ju; Kim, Han-Suk; Kim, Se-Yeon; Sim, Gue Hong; Choi, Chang Won; Kim, Beyong Il; Choi, Jung-Hwan; Kim, Ee-Kyung; Kim, Eun Sun
Issue Date
2010
Publisher
KARGER
Citation
NEONATOLOGY; Vol.98 3; 245-253
Keywords
Cerebral function monitoringAmplitude-integrated EEGAminophyllinePostnatal age
Abstract
Background: The use of amplitude-integrated electroencephalography (aEEG) is increasing during the neonatal intensive care of preterm infants. Objective: This prospective study was designed to assess factors that affect the maturation of aEEG activity in preterm infants with a gestational age (GA) of <32 weeks. Methods: aEEGs with cerebral function monitoring were performed weekly in preterm infants, and the recordings were evaluated and scored to assess the degree of continuity, the degree of sleep-wake cycling, and the amplitude of the lower border. Subjects with any of the following conditions were excluded: intraventricular hemorrhage or periventricular leukomalacia on cranial ultrasonography, sedation, hypotension, or respiratory instability (FiO(2) >50%). Results: The authors analyzed 207 recordings in 35 infants (GA 24-31 weeks, birth weight 440-1,980 g, post-menstrual age 25-38 weeks). At postmenstrual age 34-36 weeks, the aEEG total score was higher in preterm infants with a GA from 24 to 28 weeks than in less premature infants with a GA from 29 to 31 weeks (aEEG total score 12 vs. 10, p < 0.05). Logistic regression analysis revealed that the sleep-wake cycling was more prominent in infants with higher postnatal age (OR 3.32, 95% CI 2.40-4.59) or those receiving aminophylline (OR 3.28, 95% CI 1.06-10.08). Conclusions: The maturation of aEEG activity was found to be significantly correlated with postnatal age and with aminophylline use in clinically stable preterm infants. Most notably, aminophylline was found to be significantly associated with the degree of sleep-wake cycling as indicated by aEEG activity. Copyright (C) 2010 S. Karger AG, Basel
ISSN
1661-7800
Language
English
URI
http://hdl.handle.net/10371/76981
DOI
https://doi.org/10.1159/000277936
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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