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Clinical Application of Liver MR Imaging in Wilson`s Disease

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors
Cheon, Jung-Eun; Kim, In-One; Seo, Jeong Kee; Ko, Jae Sung; Shin, Cheong-Il; Yeon, Kyung Mo; Kim, Woo Sun; Lee, Jeong Min
Issue Date
2010-12
Publisher
KOREAN RADIOLOGICAL SOC
Citation
KOREAN JOURNAL OF RADIOLOGY; Vol.11 6; 665-672
Keywords
Hepatolenticular degenerationLiverMagnetic resonance (MR)
Abstract
Objective: To determine whether there is a correlation between liver MR findings and the clinical manifestations and severity of liver dysfunction in patients with Wilson`s disease. Materials and Methods: Two radiologists retrospectively evaluated MR images of the liver in 50 patients with Wilson`s disease. The Institutional Review Board approved this retrospective study and informed consent was waived. MR images were evaluated with a focus on hepatic contour abnormalities and the presence of intrahepatic nodules. By using Fisher`s exact test, MR findings were compared with clinical presentations (neurological and non-neurological) and hepatic dysfunction, which was categorized by the Child-Pugh classification system (A, B and C). Follow-up MR images were available for 17 patients. Results: Contour abnormalities of the liver and intrahepatic nodules were observed in 31 patients (62%) and 25 patients (50%), respectively. Each MR finding showed a statistically significant difference (p < 0.05) among the three groups of Child-Pugh classifications (A, n = 36; B, n = 5; C, n = 9), except for splenomegaly (p = 0.243). The mean age of the patients with positive MR findings was higher than that of patients with negative MR findings. For patients with Child-Pugh class A (n = 36) with neurological presentation, intrahepatic nodules, surface nodularity, and gallbladder fossa widening were more common. Intrahepatic nodules were improved (n = 8, 47%), stationary (n = 5, 29%), or aggravated (n = 4, 24%) on follow-up MR images. Conclusion: MR imaging demonstrates the contour abnormalities and parenchymal nodules of the liver in more than half of the patients with Wilson`s disease, which correlates with the severity of hepatic dysfunction and clinical manifestations.
ISSN
1229-6929
Language
English
URI
http://hdl.handle.net/10371/76996
DOI
https://doi.org/10.3348/kjr.2010.11.6.665
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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