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Protective Role of COMP-Ang1 in Ischemic Rat Brain

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dc.contributor.authorShin, Hye Young-
dc.contributor.authorLee, Yoon Jin-
dc.contributor.authorKim, Hak Joo-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorWang, Kyu Chang-
dc.contributor.authorKoh, Gou Young-
dc.contributor.authorPaek, Sun Ha-
dc.contributor.authorKim, Dong Gyu-
dc.contributor.authorKim, Jong Hoon-
dc.date.accessioned2012-06-14T01:29:54Z-
dc.date.available2012-06-14T01:29:54Z-
dc.date.issued2010-04-
dc.identifier.citationJOURNAL OF NEUROSCIENCE RESEARCH; Vol.88 5; 1052-1063ko_KR
dc.identifier.issn0360-4012-
dc.identifier.urihttp://hdl.handle.net/10371/77063-
dc.description.abstractIn cerebral ischemia, the induction of angiogenesis may represent a natural defense mechanism that enables the hypoxic brain to avoid progression into infarction. Angiopoietin-1 (Ang1) is known to produce non-leaky and stable blood vessel formation mainly by the Tie2 receptor. Therefore, we envisioned that the application of cartilage oligomeric matrix protein-Ang1 (COMP-Ang1), a soluble, stable, and potent form of Ang1, would promote angiogenesis and provide a protective effect following unilateral middle cerebral artery occlusion (MCAO) in rats. To this end, we employed a 2-hour-MCAO model, and treated rats with adenovirus encoding COMP-Ang1 (Ade-COMP-Ang1) or control virus encoding beta-gal (Ade-beta-gal). Time course magnetic resonance images (MRIs) revealed significantly reduced infarct volume in the rats treated with Ade-COMP-Ang1 with an improvement of post-ischemic neurological deficits compared with rats treated with Ade-beta-gal. Moreover, compared to the rats treated with Ade-beta-gal, the rats treated with Ade-COMP-Ang1 showed an increase in blood vessels, especially in the border zone adjacent to the infarction, increased number of endogenous neuronal progenitor cells in the ischemic brain, and decreased number of TUNEL-positive cells. Taken together, COMP-Ang1 reduced infarct volume and consequently attenuated post-ischemic neurological deficits through enhanced angiogenesis and increased viable cell mass of neuronal cells.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-LISSko_KR
dc.subjectBlood vesselsko_KR
dc.subjectcerebral ischemiako_KR
dc.subjectNeurogenesisko_KR
dc.subjectischaemiako_KR
dc.subjectNeuroprotectionko_KR
dc.subjectGene transferko_KR
dc.titleProtective Role of COMP-Ang1 in Ischemic Rat Brainko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor신혜영-
dc.contributor.AlternativeAuthor이윤진-
dc.contributor.AlternativeAuthor김학주-
dc.contributor.AlternativeAuthor박철기-
dc.contributor.AlternativeAuthor김종훈-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor김동규-
dc.contributor.AlternativeAuthor고구영-
dc.contributor.AlternativeAuthor백선하-
dc.identifier.doi10.1002/jnr.22274-
dc.citation.journaltitleJOURNAL OF NEUROSCIENCE RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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