Browse

Preoperative Nomograms for Predicting Extracapsular Extension in Korean Men with Localized Prostate Cancer: A Multi-institutional Clinicopathologic Study

Cited 12 time in Web of Science Cited 14 time in Scopus
Authors
Chung, Jae Seung; Choi, Han Yong; Song, Hae-Ryoung; Byun, Seok-Soo; Song, Cheryn; Lee, Sang Eun; Lee, Eun Sik; Chung, Moon Kee; Yu, Ho Song; Choi, Young Deuk; Jung, Tae Young; Kim, Won-Jae; Ahn, Hanjong; Cho, Jin Seon; Seo, Seong il
Issue Date
2010-10
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 10; 1443-1448
Keywords
NomogramsPatient SelectionProstatic neoplasmsProstatectomy
Abstract
We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5%) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy.
ISSN
1011-8934
Language
English
URI
http://hdl.handle.net/10371/77072
DOI
https://doi.org/10.3346/jkms.2010.25.10.1443
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse