Publications
Detailed Information
Pathologic Complete Response of Primary Tumor Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Long-term Outcomes and Prognostic Significance of Pathologic Nodal Status (KROG 09-01)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Chang, Hee Jin | - |
dc.contributor.author | Park, Won | - |
dc.contributor.author | Nam, Heerim | - |
dc.contributor.author | Cho, Moon-June | - |
dc.contributor.author | Park, Jin-hong | - |
dc.contributor.author | Koom, Woong Sub | - |
dc.contributor.author | Lee, Kyung-Ja | - |
dc.contributor.author | Kim, Jung Soo | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Nam, Taek-Keun | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Kang, Min Kyu | - |
dc.contributor.author | Kim, Jong Hoon | - |
dc.contributor.author | Kim, Jun-Sang | - |
dc.contributor.author | Choi, Doo Ho | - |
dc.contributor.author | Oh, Jae Hwan | - |
dc.date.accessioned | 2012-06-15T05:32:10Z | - |
dc.date.available | 2012-06-15T05:32:10Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | ANNALS OF SURGERY; Vol.252 6; 998-1004 | ko_KR |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77101 | - |
dc.description.abstract | Objective: To investigate long-term outcomes of locally advanced rectal cancer (LARC) patients with postchemoradiotherapy (post-CRT) pathologic complete response of primary tumor (ypT0) and determine prognostic significance of post-CRT pathologic nodal (ypN) status. Background: LARC patients with post-CRT pathologic complete response were suggested to have favorable long-term outcomes, but prognostic significance of ypN status has never been specifically defined in ypT0 patients. Methods: The Korean Radiation Oncology Group collected clinical data for 333 LARC patients with ypT0 following preoperative CRT and curative radical resections between 1993 and 2007. Sphincter preservation surgery and abdominoperineal resection were performed in 283 (85.0%) and 50 (15.0%) patients, respectively. Postoperative chemotherapy was given to 285 (85.6%) patients. Survival was estimated by the Kaplan-Meier method, and the Cox proportional hazard model was used in multivariate analyses. Results: After median follow-up of 43 (range = 14-172) months, 5-year disease-free survival (DFS) was 84.6% and overall survival (OS) was 92.8%. The ypN status was ypT0N0 in 304 (91.3%), ypT0N1 in 22 (6.6%), and ypT0N2 in 7 (2.1%) patients. The ypN status was the most relevant independent prognostic factor for both DFS and OS in ypT0 patients. The 5-year DFS and OS was 88.5% and 94.8% in ypT0N0 patients, and 45.2% and 72.8% in ypT0N+ patients (both, P < 0.001). Conclusions: LARC patients achieving ypT0N0 after preoperative CRT had favorable long-term outcomes, whereas positive ypN status had a poor prognosis even after total regression of primary tumor. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | ko_KR |
dc.title | Pathologic Complete Response of Primary Tumor Following Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Long-term Outcomes and Prognostic Significance of Pathologic Nodal Status (KROG 09-01) | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 여승구 | - |
dc.contributor.AlternativeAuthor | 김대용 | - |
dc.contributor.AlternativeAuthor | 김태현 | - |
dc.contributor.AlternativeAuthor | 장희진 | - |
dc.contributor.AlternativeAuthor | 오재환 | - |
dc.contributor.AlternativeAuthor | 박원 | - |
dc.contributor.AlternativeAuthor | 최두호 | - |
dc.contributor.AlternativeAuthor | 남희림 | - |
dc.contributor.AlternativeAuthor | 김준상 | - |
dc.contributor.AlternativeAuthor | 조문준 | - |
dc.contributor.AlternativeAuthor | 김종훈 | - |
dc.contributor.AlternativeAuthor | 박진홍 | - |
dc.contributor.AlternativeAuthor | 강민규 | - |
dc.contributor.AlternativeAuthor | 금웅섭 | - |
dc.contributor.AlternativeAuthor | 김재성 | - |
dc.contributor.AlternativeAuthor | 남택근 | - |
dc.contributor.AlternativeAuthor | 지의규 | - |
dc.contributor.AlternativeAuthor | 김정수 | - |
dc.contributor.AlternativeAuthor | 이경자 | - |
dc.identifier.doi | 10.1097/SLA.0b013e3181f3f1b1 | - |
dc.citation.journaltitle | ANNALS OF SURGERY | - |
dc.description.citedreference | Habr-Gama A, 2009, BRIT J SURG, V96, P125, DOI 10.1002/bjs.6470 | - |
dc.description.citedreference | Capirci C, 2008, INT J RADIAT ONCOL, V72, P99, DOI 10.1016/j.ijrobp.2007.12.019 | - |
dc.description.citedreference | Glynne-Jones R, 2008, DIS COLON RECTUM, V51, P10, DOI 10.1007/s10350-007-9080-8 | - |
dc.description.citedreference | GLYNNEJONES R, 2008, DIS COLON RECTUM, V51, P19 | - |
dc.description.citedreference | Collette L, 2007, J CLIN ONCOL, V25, P4379, DOI 10.1200/JCO.2007.11.9685 | - |
dc.description.citedreference | Minsky BD, 2007, J CLIN ONCOL, V25, P4339, DOI 10.1200/JCO.2007.12.8892 | - |
dc.description.citedreference | Kim IJ, 2007, DIS COLON RECTUM, V50, P1342, DOI 10.1007/s10350-007-277-7 | - |
dc.description.citedreference | Shivnani AT, 2007, AM J SURG, V193, P389, DOI 10.1016/j.amjsurg.2006.09.030 | - |
dc.description.citedreference | SHIVNANI AT, 2007, AM J SURG, V193, P393 | - |
dc.description.citedreference | Glynne-Jones R, 2006, INT J RADIAT ONCOL, V66, P319, DOI 10.1016/j.ijrobp.2006.05.047 | - |
dc.description.citedreference | Johnston PG, 2006, J CLIN ONCOL, V24, P4049, DOI 10.1200/JCO.2006.06.6530 | - |
dc.description.citedreference | Liersch T, 2006, J CLIN ONCOL, V24, P4062, DOI 10.1200/JCO.2005.04.2739 | - |
dc.description.citedreference | Fietkau R, 2006, DIS COLON RECTUM, V49, P1284, DOI 10.1007/s10350-006-0570-x | - |
dc.description.citedreference | Stipa F, 2006, ANN SURG ONCOL, V13, P1047, DOI 10.1245/ASO.2006.03.053 | - |
dc.description.citedreference | Kim DW, 2006, CANCER, V106, P1694, DOI 10.1002/cncr.21794 | - |
dc.description.citedreference | Coco C, 2006, DIS COLON RECTUM, V49, P311, DOI 10.1007/s10350-005-0291-6 | - |
dc.description.citedreference | Hughes R, 2006, INT J COLORECTAL DIS, V21, P11, DOI 10.1007/s00384-005-0749-y | - |
dc.description.citedreference | KIM NK, 2006, DIS COLON RECTUM, V499, P1284 | - |
dc.description.citedreference | Lezoche E, 2005, BRIT J SURG, V92, P1546, DOI 10.1002/bjs.5178 | - |
dc.description.citedreference | Rodel C, 2005, J CLIN ONCOL, V23, P8688, DOI 10.1200/JCO.2005.02.1329 | - |
dc.description.citedreference | Guillem JG, 2005, ANN SURG, V241, P829, DOI 10.1097/01.sla.0000161980.46459.96 | - |
dc.description.citedreference | Chen CC, 2005, DIS COLON RECTUM, V48, P722, DOI 10.1007/s10350-004-0851-1 | - |
dc.description.citedreference | Chapet O, 2005, INT J RADIAT ONCOL, V61, P1371, DOI 10.1016/j.ijrobp.2004.08.022 | - |
dc.description.citedreference | Chan AKP, 2005, INT J RADIAT ONCOL, V61, P665, DOI 10.1016/j.ijrobp.2004.06.026 | - |
dc.description.citedreference | Baxter NN, 2005, INT J RADIAT ONCOL, V61, P426, DOI 10.1016/j.ijrobp.2004.06.259 | - |
dc.description.citedreference | GUILLEM JG, 2005, ANN SURG, V241, P836 | - |
dc.description.citedreference | Bonnen M, 2004, INT J RADIAT ONCOL, V60, P1098, DOI 10.1016/j.ijrobp.2004.04.062 | - |
dc.description.citedreference | Sauer R, 2004, NEW ENGL J MED, V351, P1731 | - |
dc.description.citedreference | Habr-Gama A, 2004, ANN SURG, V240, P711, DOI 10.1097/01.sla.0000141194.27992.32 | - |
dc.description.citedreference | Michelassi F, 2004, ANN SURG, V240, P717 | - |
dc.description.citedreference | Stipa F, 2004, ANN SURG ONCOL, V11, P187, DOI 10.1245/ASO.2004.06.010 | - |
dc.description.citedreference | Garcia-Aguilar J, 2003, DIS COLON RECTUM, V46, P298, DOI 10.1097/01.DCR.0000054637.75996.DF | - |
dc.description.citedreference | Theodoropoulos G, 2002, DIS COLON RECTUM, V45, P895, DOI 10.1097/01.DCR.000009491.47145.8F | - |
dc.description.citedreference | Ruo LY, 2002, ANN SURG, V236, P75, DOI 10.1097/01.SLA.0000018656.05794.5D | - |
dc.description.citedreference | Valentini V, 2002, INT J RADIAT ONCOL, V53, P664 | - |
dc.description.citedreference | *AM JOINT COMM CAN, 2002, AJCC CANC STAG MAN, P113 | - |
dc.description.citedreference | Kim CJ, 2001, ANN SURG, V234, P352 | - |
dc.description.citedreference | Janjan NA, 2001, AM J CLIN ONCOL-CANC, V24, P107 | - |
dc.description.citedreference | Tepper JE, 2001, J CLIN ONCOL, V19, P157 | - |
dc.description.citedreference | KIM CJ, 2001, ANN SURG, V234, P358 | - |
dc.description.citedreference | HAMILTON S, 2000, WHO CLASSIFICATION T, V14, P219 | - |
dc.description.tc | 4 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.