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Quality of life and mortality from a nephrologist`s view: a prospective observational study

Cited 18 time in Web of Science Cited 20 time in Scopus
Authors
Han, Seung Seok; Kim, Ki Woong; Na, Ki Young; Chae, Dong-Wan; Kim, Suhnggwon; Chin, Ho Jun; Kim, Yon Su
Issue Date
2009-11-24
Publisher
BIOMED CENTRAL LTD
Citation
BMC NEPHROLOGY; Vol.10 ; -
Abstract
Background: Although health-related quality of life (HRQOL) is a potential independent predictor of mortality, nephrologists have shown little interest in HRQOL with respect to mortality in chronic kidney disease (CKD). The aim of this article is to evaluate the impact of HRQOL on mortality in the elderly, who are likely to develop or already have CKD. Methods: Among 1,000 randomly sampled participants aged more than 65 years (sourced from the Korean Longitudinal Study on Health and Ageing), 944 subjects were evaluated for HRQOL. HRQOL was assessed using a 36-item Short-Form health survey (SF36). A cumulative survival rate was calculated according to tertiles of SF36 scores and classified by the presence of CKD (estimated GFR <60 ml/min/1.73 m(2)). Results: Among 944 subjects, 46.6% had CKD. CKD patients had lower total and physical component scores compared with subjects without CKD. The 3-year cumulative survival rate was 90.0% (non-CKD vs. CKD: 92.6% vs. 87.4%, P = 0.005 by log rank test). After adjusting for multiple variables, a reduced SF36 score (physical and mental components) was a strong predictor of all-cause mortality. Physical components were consistently able to predict mortality after CKD classification, but mental components were statistically significant only in the CKD group. Conclusion: In addition to traditional risk factors of mortality, nephrologists should be aware of HRQOL as a predictor of mortality and should make efforts to improve HRQOL in CKD patients.
ISSN
1471-2369
Language
English
URI
http://hdl.handle.net/10371/77374
DOI
https://doi.org/10.1186/1471-2369-10-39
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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