Browse

Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics

Cited 25 time in Web of Science Cited 26 time in Scopus
Authors
Park, Byung-Lae; Park, Se-Min; Park, Jong-Sook; Uh, Soo-Taek; Kim, Yong-Hoon; Choi, Inseon S.; Cho, Sang-Heon; Lee, Yong-Won; Park, Choon-Sik; Shin, Hyoung-Doo; Lee, Jae-Young; Hong, Chein-Soo; Choi, Byoung-Whui; Kim, Mi-Kgyeong; Choi, Jae-Sung
Issue Date
2010-06-30
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS; Vol.43 6; 445-449
Keywords
Aspirin intolerant asthmaAsthmaProstaglandin E receptor(s)Single nucleotide polymorphism
Abstract
Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the 1(st) cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the 2(nd) cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the 2(nd) cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.
ISSN
1976-6696
Language
English
URI
http://hdl.handle.net/10371/77377
DOI
https://doi.org/10.5483/BMBRep.2010.43.6.445
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse