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Cerebellar Hypoperfusion during Transient Global Amnesia: An MRI and Oculographic Study

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Yang, YoungSoon; Kim, Ji Soo; Kim, SangYun; Kim, Yu Kyeong; Han, Il-Woo; Kwak, Yong Tae
Issue Date
2009-06
Publisher
KOREAN NEUROLOGICAL ASSOC
Citation
JOURNAL OF CLINICAL NEUROLOGY; Vol.5 2; 74-80
Keywords
transient global amnesiacerebellumsmooth pursuitsaccadeshippocampusMRISPECT
Abstract
Background and Purpose Transient global amnesia (TGA) is characterized by sudden anterograde and retrograde amnesia lasting for LIP to 24 hours. Diffusion-weighted magnetic resonance imaging (DWI) in cases of TGA and ischemia demonstrates a high frequency of high signal intensities restricted to the hippocampus, and this has been proposed as an etiology of TGA. The aims of this study were to characterize the DWI and single-photon-emission computed tomography (SPECT) findings during the acute and recovered phases of TGA and to correlate the findings with oculomotor abnormalities. Methods Five consecutive patients with a clinical diagnosis of TGA underwent DWI and SPECT of the brain within 24 hours after symptom onset and again 3 days later. Eye movements were also recorded using three-dimensional video-oculography. Results In all patients, DWI disclosed small punctuate (1-3 mm), high-signal lesions in the lateral portion of the hippocampus. The initial SPECT also revealed hypoperfusion in the cerebellar vermis, which had recovered by the follow-up examination. Three patients showed saccadic hypermetria or impaired smooth pursuit only during the acute phase. Conclusions Our patients with TGA showed cerebellar vermian hypoperfusion in addition to ischemic insults to the lateral hippocampus. The oculomotor abnormalities observed in our patients support the Occurrence of cerebellar dysfunction during the TGA attack. J Clin Neurol 2009;5:74-80
ISSN
1738-6586
Language
English
URI
http://hdl.handle.net/10371/77387
DOI
https://doi.org/10.3988/jcn.2009.5.2.74
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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