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Detection of Differential Proteomes of Human beta-Cells During Islet-Like Differentiation Using iTRAQ Labeling
Cited 24 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2009-03
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF PROTEOME RESEARCH; Vol.8 3; 1393-1403
- Keywords
- human beta-cell line ; RNAKT-15 cell ; iTRAQ ; islet transplantation ; beta-cell differentiation
- Abstract
- A human beta-cell line, RNAKT-15, was recently established from human pancreatic islets, whereby its differentiation into islet-like beta-cells (islet-like RNAKT-15) increased its expression of insulin 2-fold compared with RNAKT-15 cells. To characterize the differentiation of RNAKT-15 cells into islet-like RNAKT-15, microarray and quantitative proteomics were performed. Our analysis of differential proteomic and mRNA expression has resulted in a greater understanding of the molecular functions that are involved in beta-cell differentiation and insulin synthesis and release.
- ISSN
- 1535-3893
- Language
- English
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