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Preinterventional Clopidogrel Response Variability for Coil Embolization of Intracranial Aneurysms: Clinical Implications

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dc.contributor.authorKang, H. -S.-
dc.contributor.authorKwon, B. J.-
dc.contributor.authorKim, J. E.-
dc.contributor.authorHan, M. H.-
dc.date.accessioned2012-06-26T04:40:19Z-
dc.date.available2012-06-26T04:40:19Z-
dc.date.issued2010-08-
dc.identifier.citationAMERICAN JOURNAL OF NEURORADIOLOGY; Vol.31 7; 1206-1210ko_KR
dc.identifier.issn0195-6108-
dc.identifier.urihttp://hdl.handle.net/10371/77417-
dc.description.abstractBACKGROUND AND PURPOSE: Thromboembolism is one of the most serious complications in coil embolization for intracranial aneurysms, and antiplatelet premedication may reduce this complication. However, interindividual variation exists in the efficacy of CPG. This study sought to elucidate the clinical implications of preinterventional CPG response variability in patients who undergo coil embolization for intracranial aneurysms. MATERIALS AND METHODS: CPG premedication was given to 186 consecutive patients with 209 aneurysms who underwent elective coil embolization, and the response to the premedication was measured by a point-of-care antiplatelet function test (VerifyNow assay). Patients were stratified into 4 quartiles according the test results, and their correlation with the occurrence of periprocedural complications was analyzed. The contribution of a variety of variables to the high PRU was also tested. RESULTS: In this cohort, rates of thromboembolic events and all adverse events were 7.5% and 9.1%, respectively. The quartiles of the P2Y12 reaction unit of the ADP channel (PRU) showed a significant tendency toward thromboembolic events (P = .013) and all procedure-related adverse events (P = .009), while those of the BASE and percentage inhibition did not. Thromboembolic events occurred in 17.0% and procedure-related adverse events, in 21.3% of the patients in the fourth quartile. Female sex was the only significant factor related to the fourth quartile of PRU in the multiple logistic regression analysis (P = .014). CONCLUSIONS: Procedure-related thromboembolic events occurred more frequently in patients in the upper quartile with higher PRU, especially in the fourth quartile. Further study including a large number of patients is expected to confirm this finding.ko_KR
dc.language.isoenko_KR
dc.publisherAMER SOC NEURORADIOLOGYko_KR
dc.titlePreinterventional Clopidogrel Response Variability for Coil Embolization of Intracranial Aneurysms: Clinical Implicationsko_KR
dc.typeArticleko_KR
dc.identifier.doi10.3174/ajnr.A2051-
dc.citation.journaltitleAMERICAN JOURNAL OF NEURORADIOLOGY-
dc.description.citedreferencePrice MJ, 2009, AM J CARDIOL, V103, P1339, DOI 10.1016/j.amjcard.2009.01.341-
dc.description.citedreferenceJeong YH, 2009, J AM COLL CARDIOL, V53, P2009, DOI 10.1016/j.jacc.2008.12.025-
dc.description.citedreferenceCollet JP, 2009, LANCET, V373, P309, DOI 10.1016/S0140-6736(08)61845-0-
dc.description.citedreferenceMega JL, 2009, NEW ENGL J MED, V360, P354-
dc.description.citedreferenceSimon T, 2009, NEW ENGL J MED, V360, P363-
dc.description.citedreferenceKwon BJ, 2008, NEUROSURGERY, V63, P676, DOI 10.1227/01.NEU.0000325500.73330.C2-
dc.description.citedreferencePatti G, 2008, J AM COLL CARDIOL, V52, P1128, DOI 10.1016/j.jacc.2008.06.038-
dc.description.citedreferenceLee DH, 2008, AM J NEURORADIOL, V29, P1389, DOI 10.3174/ajnr.A1070-
dc.description.citedreferenceBrooks NP, 2008, J NEUROSURG, V108, P1095, DOI 10.3171/JNS/2008/108/6/1095-
dc.description.citedreferenceScandlyn MJ, 2008, EXPERT OPIN DRUG MET, V4, P413, DOI 10.1517/17425255.4.4.413-
dc.description.citedreferencePrabhakaran S, 2008, AM J NEURORADIOL, V29, P281, DOI 10.3174/ajnr.A0818-
dc.description.citedreferenceJakubowski JA, 2008, THROMB HAEMOSTASIS, V99, P409, DOI 10.1160/TH07-09-0575-
dc.description.citedreferenceWiviott SD, 2007, NEW ENGL J MED, V357, P2001, DOI 10.1056/NEJMoa0706482-
dc.description.citedreferenceYamada NK, 2007, AM J NEURORADIOL, V28, P1778, DOI 10.3174/ainr.A0641-
dc.description.citedreferencePaniccia R, 2007, J THROMB HAEMOST, V5, P1839-
dc.description.citedreferenceKwon OK, 2006, ACTA NEUROCHIR, V148, P1139, DOI 10.1007/s00701-006-0876-4-
dc.description.citedreferenceRies T, 2006, STROKE, V37, P1816, DOI 10.1161/01.STR.0000226933.44962.a6-
dc.description.citedreferenceMalinin A, 2006, METHOD FIND EXP CLIN, V28, P315, DOI 10.1358/mf.2006.28.5.990205-
dc.description.citedreferencevon Beckerath N, 2006, THROMB HAEMOSTASIS, V95, P910, DOI 10.1160/TH06-01-0046-
dc.description.citedreferenceBhatt DL, 2006, NEW ENGL J MED, V354, P1706-
dc.description.citedreferenceBarsky AA, 2006, J CARDIOVASC PHARM T, V11, P47-
dc.description.citedreferenceKWON OK, 2006, ACTA NEUROCHIR WIEN, V148, P1145-
dc.description.citedreferenceRoss IB, 2005, SURG NEUROL, V64, P12, DOI 10.1016/j.surneu.2004.09.045-
dc.description.citedreferenceKwon OK, 2005, AM J NEURORADIOL, V26, P894-
dc.description.citedreferencePark HK, 2005, AM J NEURORADIOL, V26, P506-
dc.description.citedreferenceSerebruany VL, 2005, J AM COLL CARDIOL, V45, P246, DOI 10.1016/j.jacc.2004.09.067-
dc.description.citedreferenceDiener HC, 2004, LANCET, V364, P331-
dc.description.citedreferenceDorsam RT, 2004, J CLIN INVEST, V113, P340, DOI 10.1172/JCI200420986-
dc.description.citedreferenceKwon BJ, 2003, NEURORADIOLOGY, V45, P562, DOI 10.1007/s00234-003-1028-7-
dc.description.citedreferenceGurbel PA, 2003, CIRCULATION, V107, P2908, DOI 10.1161/01.CIR.0000072771.11429.83-
dc.description.citedreferenceKwon BJ, 2002, INTERV NEURORADIOL, V8, P367-
dc.description.citedreferenceSteinhubl SR, 2002, JAMA-J AM MED ASSOC, V288, P2411-
dc.description.citedreferenceDerdeyn CP, 2002, J NEUROSURG, V96, P837-
dc.description.citedreferenceYusuf S, 2001, NEW ENGL J MED, V345, P494-
dc.description.citedreferencePelz DM, 1998, AM J NEURORADIOL, V19, P1541-
dc.description.citedreferenceHigashida RT, 1997, J NEUROSURG, V87, P944-
dc.description.citedreferenceMoret J, 1997, J NEURORADIOLOGY, V24, P30-
dc.description.citedreference1996, LANCET, V348, P1329-
dc.description.tc2-
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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