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Transferable Quinolone Resistance in Vibrio cholerae
DC Field | Value | Language |
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dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Wang, Minghua | - |
dc.contributor.author | Ahmed, Sabeena | - |
dc.contributor.author | Park, Chi Hye | - |
dc.contributor.author | Faruque, Abu S. G. | - |
dc.contributor.author | Khan, Wasif A. | - |
dc.contributor.author | Calderwood, Stephen B. | - |
dc.contributor.author | Hooper, David C. | - |
dc.contributor.author | Jacoby, George A. | - |
dc.contributor.author | Qadri, Firdausi | - |
dc.contributor.author | Salam, Mohammed A. | - |
dc.contributor.author | LaRocque, Regina C. | - |
dc.date.accessioned | 2012-06-26T04:53:24Z | - |
dc.date.available | 2012-06-26T04:53:24Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.citation | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Vol.54 2; 799-803 | ko_KR |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77421 | - |
dc.description.abstract | Ciprofloxacin was introduced for treatment of patients with cholera in Bangladesh because of resistance to other agents, but its utility has been compromised by the decreasing ciprofloxacin susceptibility of Vibrio cholerae over time. We correlated levels of susceptibility and temporal patterns with the occurrence of mutation in gyrA, which encodes a subunit of DNA gyrase, followed by mutation in parC, which encodes a subunit of DNA topoisomerase IV. We found that ciprofloxacin activity was more recently further compromised in strains containing qnrVC3, which encodes a pentapeptide repeat protein of the Qnr subfamily, members of which protect topoisomerases from quinolone action. We show that qnrVC3 confers transferable low-level quinolone resistance and is present within a member of the SXT integrating conjugative element family found commonly on the chromosomes of multidrug-resistant strains of V. cholerae and on the chromosomes of Escherichia coli transconjugants constructed in the laboratory. Thus, progressive increases in quinolone resistance in V. cholerae are linked to cumulative mutations in quinolone targets and most recently to a qnr gene on a mobile multidrug resistance element, resulting in further challenges for the antimicrobial therapy of cholera. | ko_KR |
dc.description.sponsorship | This work was supported in part by grants R01 AI57576 (to
D.C.H.), R01 AI43312 (to G.A.J.), U01 AI058935 (to S.B.C.), and K01 TW07144 (to R.C.L.) from United States Public Health Service, National Institutes of Health, and by a grant from the Ministry of Science and Technology, National Basic Research Program of China, 2005CB0523101 (to M.W.). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC MICROBIOLOGY | ko_KR |
dc.title | Transferable Quinolone Resistance in Vibrio cholerae | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.contributor.AlternativeAuthor | 박지혜 | - |
dc.identifier.doi | 10.1128/AAC.01045-09 | - |
dc.citation.journaltitle | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | - |
dc.description.citedreference | Strahilevitz J, 2009, CLIN MICROBIOL REV, V22, P664, DOI 10.1128/CMR.00016-09 | - |
dc.description.citedreference | Bin Kim H, 2009, ANTIMICROB AGENTS CH, V53, P639, DOI 10.1128/AAC.01051-08 | - |
dc.description.citedreference | Sanchez MB, 2008, BMC MICROBIOL, V8, DOI 10.1186/1471-2180-8-148 | - |
dc.description.citedreference | Crump JA, 2008, ANTIMICROB AGENTS CH, V52, P1278, DOI 10.1128/AAC.01509-07 | - |
dc.description.citedreference | *CLSI, 2008, PERF STAND ANT SUSC | - |
dc.description.citedreference | FONSECA EL, 2008, EMERG INFECT DIS, V14, P1129 | - |
dc.description.citedreference | Cattoir V, 2007, ANTIMICROB AGENTS CH, V51, P2650, DOI 10.1128/AAC.00070-07 | - |
dc.description.citedreference | Mazel D, 2006, NAT REV MICROBIOL, V4, P608, DOI 10.1038/nrmicro1462 | - |
dc.description.citedreference | Saha D, 2006, NEW ENGL J MED, V354, P2452, DOI 10.1056/NEJMoa054493 | - |
dc.description.citedreference | Burrus V, 2006, PLASMID, V55, P173, DOI 10.1016/j.plasmid.2006.01.001 | - |
dc.description.citedreference | Faruque SM, 2006, J INFECT DIS, V193, P1029 | - |
dc.description.citedreference | Poirel L, 2005, J ANTIMICROB CHEMOTH, V56, P1118, DOI 10.1093/jac/dki371 | - |
dc.description.citedreference | Saha D, 2005, LANCET, V366, P1085, DOI 10.1016/S0140-6736(05)67290-X | - |
dc.description.citedreference | Tran JH, 2005, ANTIMICROB AGENTS CH, V49, P3050, DOI 10.1128/AAC.49.7.3050-3052.2005 | - |
dc.description.citedreference | Biskri L, 2005, J BACTERIOL, V187, P1740, DOI 10.1128/JB.187.5.1740-1750.2005 | - |
dc.description.citedreference | Tran JH, 2005, ANTIMICROB AGENTS CH, V49, P118, DOI 10.1128/AAC.49.1.118-125.2005 | - |
dc.description.citedreference | Saha D, 2004, J INFECT DIS, V189, P2318 | - |
dc.description.citedreference | Huda N, 2003, ANTIMICROB AGENTS CH, V47, P2413, DOI 10.1128/AAC.47.8.2413-2417.2003 | - |
dc.description.citedreference | Huda MN, 2003, MICROBIOL IMMUNOL, V47, P419 | - |
dc.description.citedreference | HOOPER DC, 2003, QUINOLONE ANTIMICROB, P41 | - |
dc.description.citedreference | Baranwal S, 2002, ANTIMICROB AGENTS CH, V46, P2676, DOI 10.1128/AAC.46.8.2676-2678.2002 | - |
dc.description.citedreference | Hochhut B, 2001, ANTIMICROB AGENTS CH, V45, P2991 | - |
dc.description.citedreference | Huda MN, 2001, FEMS MICROBIOL LETT, V203, P235, DOI 10.1016/S0378-1097(01)00363-9 | - |
dc.description.citedreference | Rowe-Magnus DA, 2001, P NATL ACAD SCI USA, V98, P652 | - |
dc.description.citedreference | Khan WA, 1996, LANCET, V348, P296 | - |
dc.description.citedreference | BARKER A, 1994, J BACTERIOL, V176, P5450 | - |
dc.description.citedreference | YOSHIDA H, 1991, ANTIMICROB AGENTS CH, V35, P1647 | - |
dc.description.citedreference | YOSHIDA H, 1990, ANTIMICROB AGENTS CH, V34, P1271 | - |
dc.description.citedreference | STOLL BJ, 1982, BRIT MED J, V285, P1185 | - |
dc.description.tc | 0 | - |
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