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Perfusion Computed Tomography Evaluation of Cerebral Hemodynamic Impairment in Patients With Unilateral Chronic Steno-Occlusive Disease: A Comparison With the Acetazolamide Challenge (99m)Tc-Hexamethylpropyleneamine Oxime Single-Photon Emission Computed Tomography

Cited 8 time in Web of Science Cited 10 time in Scopus
Authors
Kim, Eunhee; Sohn, Chul-Ho; Na, Dong Gyu; Kim, Jeong Eun; Kim, Ji-hoon; Jeon, Se Jeong; Chang, Kee-Hyun
Issue Date
2009-08
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY; Vol.33 4; 546-551
Keywords
SPECTPCTcerebral vascular reserve
Abstract
Purpose: The purpose of this study was to determine which pefusion computed tomography (PCT) parameter is the most valid predictor of cerebral vascular reserve (CVR) as determined by (99m)Tc-hexamethylpropylencamine oxime single-photon emission computed tomography (SPECT). Methods: Single-photon emission computed tomography with acetazolamide challenge and PCT were used in 23 patients with unilateral steno-occlusive vascular disease. After coregistration of the PCT and SPECT images, we assessed the relationship between the PCT parameters and SPECT findings and the predictive values of the PCT parameters for decreased CVR. Results: All PCT parameters of cerebral blood flow, cerebral blood volume, and mean transit time (MTT) were significantly correlated with SPECT regional cerebral blood flow ratios (P < 0.01). The MTT values more strongly correlated with acetazolamide effect than with cerebral blood volume or cerebral blood flow (P < 0.001). The MTT difference (values in the pathological hemisphere minus the values in the contralateral hemisphere) was a threshold of 1.5 seconds, with a sensitivity of 88% and a specificity of 70% for predicting decreased CVR. Conclusion: Mean transit time is the most predictive parameter for assessing decreased CVR in patients with unilateral steno-occlusive vascular disease.
ISSN
0363-8715
Language
English
URI
http://hdl.handle.net/10371/77457
DOI
https://doi.org/10.1097/RCT.0b013e318188887d
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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