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Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less

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dc.contributor.authorKwon, Ji Hyun-
dc.contributor.authorKim, Yu Jung-
dc.contributor.authorLee, Keun-Wook-
dc.contributor.authorOh, Do-Youn-
dc.contributor.authorPark, So Yeon-
dc.contributor.authorKim, Jee Hyun-
dc.contributor.authorChie, Eui Kyu-
dc.contributor.authorKim, Sung-Won-
dc.contributor.authorIm, Seock-Ah-
dc.contributor.authorKim, In-Ah-
dc.contributor.authorKim, Tae-You-
dc.contributor.authorPark, In Ae-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorBang, Yung-Jue-
dc.contributor.authorHa, Sung Whan-
dc.date.accessioned2012-06-26T08:13:33Z-
dc.date.available2012-06-26T08:13:33Z-
dc.date.created2020-12-23-
dc.date.created2020-12-23-
dc.date.issued2010-10-15-
dc.identifier.citationBMC Cancer, Vol.10, p. 557-
dc.identifier.issn1471-2407-
dc.identifier.other119697-
dc.identifier.urihttps://hdl.handle.net/10371/77478-
dc.description.abstractBackground: Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of <= 1 cm, including T1mic. Methods: We performed a retrospective analysis of clinical and pathology data of all consecutive patients with node-negative T1mic, T1a, and T1b invasive ductal carcinoma who received surgery between Jan 2000 and Dec 2006. The recurrence free survival (RFS) and risk factors for recurrence were identified. Results: Out of 3889 patients diagnosed with breast cancer, 375 patients were enrolled (T1mic:120, T1a:93, T1b:162). Median age at diagnosis was 49. After a median follow up of 60.8 months, 12 patients developed recurrences (T1mic:4 (3.3%), T1a:2 (2.2%), T1b:6 (3.7%)), with a five-year cumulative RFS rate of 97.2%. Distant recurrence was identified in three patients. Age younger than 35 years (HR 4.91; 95% CI 1.014-23.763, p = 0.048) and triple negative disease (HR 4.93; 95% CI 1.312-18.519, p = 0.018) were significantly associated with a higher rate of recurrence. HER2 overexpression, Ki-67, and p53 status did not affect RFS. Conclusions: Prognosis of node-negative breast cancer with T1mic, T1a and T1b is excellent, but patients under 35 years of age or with triple negative disease have a relatively high risk of recurrence.-
dc.language영어-
dc.language.isoenko_KR
dc.publisherBioMed Central-
dc.titleTriple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less-
dc.typeArticle-
dc.contributor.AlternativeAuthor임석아-
dc.identifier.doi10.1186/1471-2407-10-557-
dc.citation.journaltitleBMC Cancer-
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dc.description.tc4-
dc.identifier.wosid000283655700001-
dc.identifier.scopusid2-s2.0-77957924786-
dc.citation.startpage557-
dc.citation.volume10-
dc.identifier.sci000283655700001-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorLee, Keun-Wook-
dc.contributor.affiliatedAuthorOh, Do-Youn-
dc.contributor.affiliatedAuthorPark, So Yeon-
dc.contributor.affiliatedAuthorKim, Jee Hyun-
dc.contributor.affiliatedAuthorChie, Eui Kyu-
dc.contributor.affiliatedAuthorKim, Sung-Won-
dc.contributor.affiliatedAuthorIm, Seock-Ah-
dc.contributor.affiliatedAuthorKim, In-Ah-
dc.contributor.affiliatedAuthorKim, Tae-You-
dc.contributor.affiliatedAuthorPark, In Ae-
dc.contributor.affiliatedAuthorNoh, Dong-Young-
dc.contributor.affiliatedAuthorBang, Yung-Jue-
dc.contributor.affiliatedAuthorHa, Sung Whan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusBREAST-CANCER PATIENTS-
dc.subject.keywordPlusCLINICAL CHARACTERISTICS-
dc.subject.keywordPlusNATURAL-HISTORY-
dc.subject.keywordPlusLOW-GRADE-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusAMPLIFICATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPATTERNS-
dc.subject.keywordPlusOUTCOMES-
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  • Department of Medicine
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