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Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less
DC Field | Value | Language |
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dc.contributor.author | Kwon, Ji Hyun | - |
dc.contributor.author | Kim, Yu Jung | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Park, So Yeon | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kim, In-Ah | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Park, In Ae | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Ha, Sung Whan | - |
dc.date.accessioned | 2012-06-26T08:13:33Z | - |
dc.date.available | 2012-06-26T08:13:33Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2010-10-15 | - |
dc.identifier.citation | BMC Cancer, Vol.10, p. 557 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.other | 119697 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77478 | - |
dc.description.abstract | Background: Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of <= 1 cm, including T1mic. Methods: We performed a retrospective analysis of clinical and pathology data of all consecutive patients with node-negative T1mic, T1a, and T1b invasive ductal carcinoma who received surgery between Jan 2000 and Dec 2006. The recurrence free survival (RFS) and risk factors for recurrence were identified. Results: Out of 3889 patients diagnosed with breast cancer, 375 patients were enrolled (T1mic:120, T1a:93, T1b:162). Median age at diagnosis was 49. After a median follow up of 60.8 months, 12 patients developed recurrences (T1mic:4 (3.3%), T1a:2 (2.2%), T1b:6 (3.7%)), with a five-year cumulative RFS rate of 97.2%. Distant recurrence was identified in three patients. Age younger than 35 years (HR 4.91; 95% CI 1.014-23.763, p = 0.048) and triple negative disease (HR 4.93; 95% CI 1.312-18.519, p = 0.018) were significantly associated with a higher rate of recurrence. HER2 overexpression, Ki-67, and p53 status did not affect RFS. Conclusions: Prognosis of node-negative breast cancer with T1mic, T1a and T1b is excellent, but patients under 35 years of age or with triple negative disease have a relatively high risk of recurrence. | - |
dc.language | 영어 | - |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | - |
dc.title | Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1186/1471-2407-10-557 | - |
dc.citation.journaltitle | BMC Cancer | - |
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dc.description.tc | 4 | - |
dc.identifier.wosid | 000283655700001 | - |
dc.identifier.scopusid | 2-s2.0-77957924786 | - |
dc.citation.startpage | 557 | - |
dc.citation.volume | 10 | - |
dc.identifier.sci | 000283655700001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Park, So Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Chie, Eui Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Sung-Won | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kim, In-Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae-You | - |
dc.contributor.affiliatedAuthor | Park, In Ae | - |
dc.contributor.affiliatedAuthor | Noh, Dong-Young | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Ha, Sung Whan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BREAST-CANCER PATIENTS | - |
dc.subject.keywordPlus | CLINICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | LOW-GRADE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordPlus | OUTCOMES | - |
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