S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy
- Kim, Dae-Hee; Kim, Yong-Jin; Chang, Sung-A; Lee, Hye-Won; Kim, Hyung-Kwan; Sohn, Dae-Won; Park, Young-Bae; Chang, Hyuk-Jae; Kim, Ha-Na
- Issue Date
- OXFORD UNIV PRESS
- EUROPEAN JOURNAL OF HEART FAILURE; Vol.12 10; 1051-1060
- To evaluate the protective effect of thalidomide, a potent anti-inflammatory drug, on the development of diabetic cardiomyopathy (DMCMP). We induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10). Ten weeks after diabetes induction, heart and lung mass indices were higher in the DM-N group compared with the control group. In the DM-T group, increases in heart and lung mass indices were attenuated compared with the DM-N group. On echocardiographic examination, systolic and diastolic mitral annulus velocities were impaired in the DM-N group, but they remained normal in the DM-T group. On haemodynamic analyses, left ventricular (LV) systolic function, represented by end-systolic elastance (0.35 +/- 0.14 vs. 0.18 +/- 0.07 mmHg/mu l, P < 0.001) and preload-recruitable stroke work (90.5 +/- 24.3 vs. 51.8 +/- 22.0 mmHg, P < 0.001), was preserved in the DM-T group compared with the DM-N group. Likewise, deterioration of LV diastolic function was attenuated in the DM-T group. Increases in serum levels of TNF-alpha were attenuated in the DM-T group compared with the DM-N group. On histological analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-alpha, IL-1 beta, ICAM-1, and VCAM-1. In an animal model of DMCMP, deterioration of LV systolic and diastolic function was partially prevented by thalidomide treatment.
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