S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells
- Lee, Jeong-Hoon; Yoon, Jung-Hwan; Yu, Su Jong; Chung, Goh Eun; Kim, Hwi Young; Choi, Dae Hee; Kim, Yoon Jun; Lee, Hyo-Suk; Kim, Chung Yong; Myung, Sun Jung; Kim, Bo Hyun; Jung, Eun Uk
- Issue Date
- ELSEVIER IRELAND LTD
- CANCER LETTERS; Vol.295 2; 229-235
- Cellular retinoic acid binding protein-II; Hepatocellular carcinoma; Retinoic acid; Apoptosis; Hypoxia
- Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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