Browse

HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis

Cited 63 time in Web of Science Cited 74 time in Scopus
Authors
Kim, Sae-Hoon; Kim, Myunghwa; Lee, Kyung Wha; Kim, Sang-Heon; Park, Heung-Woo; Jee, Young-Koo; Kang, Hye-Ryun
Issue Date
2010-06
Publisher
FUTURE MEDICINE LTD
Citation
PHARMACOGENOMICS; Vol.11 6; 879-884
Keywords
carbonic anhydrase inhibitortoxic epidermal necrolysishuman leukocyte antigenmethazolamideStevens-Johnson syndrome
Abstract
Aims: The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports. This study examined the disease-associated B*59 allele and investigated the association of these diseases with other HLA class I alleles. Methods: We performed high-resolution HLA-A, -B and -C genotyping in five patients with methazolamide-induced SJS/TEN using a PCR-sequencing-based typing method and analyzed the association between HLA-class I alleles and occurrence of methazolamide-induced SJS/TEN. Results: B*5901 and Cw*0102 alleles were observed in all patients and A*2402 was observed in four patients. The B*5901 allele showed the strongest association with methazolamide-induced SJS/TEN (p < 0.001; odds ratio: 249.8; 95% Cl: 13.4-4813.5), followed by Cw*0102 (p = 0.004; odds ratio: 22.1; 95% Cl: 1.2-414.3), when compared with the general population as a control. The frequency of the patients carrying B*5901, Cw*0102 and A*2402 simultaneously was significantly higher than that in the general population (p < 0.001; odds ratio: 110.1; 95% Cl: 11.7-1038.6). Conclusion: A strong association was observed between HLA-B*5901 and methazolamide-induced SJS/TEN in Korean patients. HLA-B*5901 may be a useful screening marker for predicting methazolamide-induced SJS/TEN in patients of Korean and Japanese ancestry.
ISSN
1462-2416
Language
English
URI
http://hdl.handle.net/10371/77623
DOI
https://doi.org/10.2217/PGS.10.54
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse