S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Three phenotypes of obstructive lung disease in the elderly
- Jo, K-W.; Ra, S. W.; Chae, E. J.; Seo, J. B.; Lee, J-H.; Lee, Y. K.; Huh, J. W.; Lee, J. H.; Lim, S. Y.; Oh, Y-M.; Lee, S-D.; Lee, J. S.; Sheen, S. S.; Yoon, H. I.; Shin, T. R.; Lee, S-M.; Kim, W. J.; Kim, T-H.; Kim, E-K.; Kim, N. K.
- Issue Date
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE; Vol.14 11; 1481-1488
- SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To classify the phenotypes in elderly subjects with obstructive lung disease (OLD). METHODS: We analysed 191 subjects aged >= 60 years with chronic respiratory symptoms and either obstructive spirometry or bronchial hyperresponsiveness. Factor analysis was performed using commonly measured variables and revealed four significant variables: 1) the ratio of inspiratory capacity to total lung capacity, 2) the total score on the St George`s Respiratory Questionnaire, 3) the volume fraction of the lung less than 950 Hounsfield Unit at full inspiration on volumetric computed tomography and 4) post-bronchodilator forced expiratory volume in 1 second (FEV(1)) changes. We performed a cluster analysis on these four variables. RESULTS: The mean age was 68.5 (+/- 5.2 SD) years and the mean post-bronchodilator FEV(1) was 52.4% (+/- 16.5) predicted. Three clusters with the following phenotypes were identified: Cluster 1 included subjects with moderate to severe airflow obstruction and bronchodilator reversibility; Cluster 2 subjects had moderate airflow obstruction without bronchodilator reversibility, and Cluster 3 subjects had severe airflow obstruction without bronchodilator reversibility. CONCLUSIONS: We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype.
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