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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

Cited 179 time in Web of Science Cited 186 time in Scopus
Authors
Yamauchi, Toshimasa; Hara, Kazuo; Maeda, Shiro; Yasuda, Kazuki; Horikoshi, Momoko; Fujita, Hayato; Cauchi, Stephane; Ma, Ronald C. W.; Kubo, Michiaki; Jorgensen, Torben; Witte, Daniel R.; Andersen, Gitte; Shin, Hyoung Doo; Shojima, Nobuhiro; Iwabu, Masato; Okada-Iwabu, Miki; Maegawa, Hiroshi; Watada, Hirotaka; Kawamori, Ryuzo; Kashiwagi, Atsunori; Tanaka, Yasushi; Ito, Chikako; Tai, E. Shyong; Park, Kyong Soo; Chan, Juliana C. N.; Beury, Delphine; So, Wing-Yee; Kadowaki, Takashi; Nakamura, Yusuke; Kamatani, Naoyuki; Pedersen, Oluf; Froguel, Philippe; Kasuga, Masato; Hirose, Hiroshi; Kaku, Kohei; Saito, Ikuo; Omori, Shintaro; Ohshige, Toshihiko; Hansen, Torben; Sandbaek, Annelli; Lauritzen, Torsten; Tsunoda, Tatsuhiko; Ng, Daniel P. K.; Grarup, Niels; Nakamura, Masahiro; Takahashi, Atsushi
Issue Date
2010-10
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE GENETICS; Vol.42 10; 864-869
Abstract
We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 x 10(-9); rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 x 10(-9)). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 x 10(-14), whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
ISSN
1061-4036
Language
English
URI
http://hdl.handle.net/10371/77677
DOI
https://doi.org/10.1038/ng.660
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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