Browse

Lipid Profiles and Bone Mineral Density in Pre- and Postmenopausal Women in Korea

Cited 37 time in Web of Science Cited 39 time in Scopus
Authors
Jeong, In-Kyong; Cho, Sun Wook; Kim, Sang Wan; Choi, Hyung Jin; Kim, Seong Yeon; Cho, Sang-Heon; Shin, Chan Soo; Oh, Byung-Hee; Lee, Hong Kyu; Park, Kyong Soo
Issue Date
2010-12
Publisher
SPRINGER
Citation
CALCIFIED TISSUE INTERNATIONAL; Vol.87 6; 507-512
Keywords
CholesterolOsteoporosisBone mineral density
Abstract
Although it has been hypothesized that an atherogenic lipid profile might be associated with lower bone mineral density (BMD), the previous results are controversial. We investigated the association between lipid profile and BMD in premenopausal and postmenopausal women in a large Korean population. This study considered 10,402 women who underwent measurements of lipid profile and BMD from October 2003 to October 2005 at Healthcare System Gangnam Center, Seoul National University Hospital. Participants with potential confounding factors affecting BMD (n = 3,128) were excluded. The associations between lipid profiles (total cholesterol [TC], low-density lipoprotein [LDL-C] and high-density lipoprotein [HDL-C] cholesterol, and triglyceride [TG]) and BMD at various skeletal sites (lumbar spine [L1-L4], proximal total hip, femoral neck, and trochanter) were explored by Pearson`s correlation and partial correlation, adjusting for age, body mass index, and menarche age. Multiple linear regression analyses adjusting for all other covariates were also performed. Data on 4,613 premenopausal and 2,661 postmenopausal women aged 20-91 years were finally included in the analysis. In multivariate analyses, there was no significant relationship between lipid profiles and BMD, except that HDL-C was positively associated with BMD at only the lumbar spine in postmenopausal women and that the quartiles of TG were negatively associated with BMD at the total hip and trochanter in only premenopausal women. We conclude that although there were some weak associations between lipid profiles and BMD, the results of this study hardly support the hypothesis that an atherogenic lipid profile is associated with osteoporosis.
ISSN
0171-967X
Language
English
URI
http://hdl.handle.net/10371/77694
DOI
https://doi.org/10.1007/s00223-010-9427-3
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse