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Porcine Aortic Endothelial Cell Genes Responsive to Selected Inflammatory Stimulators

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dc.contributor.authorYeom, Hye-Jung-
dc.contributor.authorShin, Kum-Joo-
dc.contributor.authorKim, Jun-Sub-
dc.contributor.authorKim, Seung-Jun-
dc.contributor.authorPaul, Saswati-
dc.contributor.authorAhn, Curie-
dc.contributor.authorChung, Junho-
dc.contributor.authorHwang, Seung Young-
dc.contributor.authorSeong, Je Kyung-
dc.contributor.authorHan, Jung-Won-
dc.contributor.authorLee, Sukmook-
dc.date.accessioned2012-06-28T04:19:25Z-
dc.date.available2012-06-28T04:19:25Z-
dc.date.issued2009-11-
dc.identifier.citationJOURNAL OF VETERINARY MEDICAL SCIENCE; Vol.71(11); 1499-1508ko_KR
dc.identifier.issn0916-7250-
dc.identifier.urihttp://hdl.handle.net/10371/77740-
dc.description.abstractUse of porcine tissues has been suggested as a promising solution for severe shortage of transplantable human organs. The immediate hurdle for xenotransplantation is acute immune/inflammatory vascular rejection of the transplant. Because endothelial cells play a key role in the initiation and the amplification of inflammation, alteration of gene expression in human endothelial cells, by various inflammatory stimulators has been studied extensively. However, transcriptional changes induced by human and other inflammatory stimulators in porcine endothelial cells have thus far not been Studied. In this study, we treated porcine endothelial cells with human tumor necrosis factor (TNF)-alpha, porcine interferon (IFN)-gamma, H(2)O(2) and lypopolysaccharide (LPS) and profiled transcriptional change at I hr, 6 hr and 24 hr, using pig oligonucleotide 13K microarray. We found that mRNA Species Such as chemokine (C-X-C motif) ligand 6 (CXCL6) and Cathepsin S were significantly induced in porcine endothelial cells, as was previously reported with human endothelial cell. We also found that mRNA species including secreted frizzled-related protein 2 (SFRP2), radical S-adenosyl methionine domain containing 2 (RSAD2). structure specific recognition protein 1 (SSRP1) also were highly overexpressed in porcine endothelial cells. This result shows clues to understand underlying mechanisms of xenotransplantation rejection and the highly responsive porcine genes may serve as novel targets to be regulated for improving the function of grafted porcine donor organs.ko_KR
dc.language.isoenko_KR
dc.publisherJAPAN SOC VET SCIko_KR
dc.subjectgene expressionko_KR
dc.subjectinflammationko_KR
dc.subjectxenotransplantationko_KR
dc.subjectporcine aortic endothelial cellko_KR
dc.subjectmicroarrayko_KR
dc.titlePorcine Aortic Endothelial Cell Genes Responsive to Selected Inflammatory Stimulatorsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor염혜정-
dc.contributor.AlternativeAuthor신금주-
dc.contributor.AlternativeAuthor김준섭-
dc.contributor.AlternativeAuthor김승준-
dc.contributor.AlternativeAuthor이석묵-
dc.contributor.AlternativeAuthor한정원-
dc.contributor.AlternativeAuthor안규리-
dc.contributor.AlternativeAuthor성제경-
dc.contributor.AlternativeAuthor정준호-
dc.contributor.AlternativeAuthor황승영-
dc.identifier.doi10.1292/jvms.001499-
dc.citation.journaltitleJOURNAL OF VETERINARY MEDICAL SCIENCE-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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