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Biological Safety and Anti-hepatofibrogenic Effects of Brassica rapa (Turnip) Nanoparticle

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Authors
Park, Dae-Hun; Li, Lan; Jang, Hyung-Kwan; Kim, Young-Jin; Choi, Yeon Shik; Lee, Min-Jae; Park, Seung-Kee; Jang, Ja-June
Issue Date
2009-12-31
Publisher
KOREAN SOC TOXICOGENOMICS & TOXICOPROTEOMICS
Citation
MOLECULAR & CELLULAR TOXICOLOGY; Vol.5 4; 317-322
Keywords
Brassica rapaTurnip nanoparticleBiological safetyHepatic fibrosis
Abstract
Hepatic fibrosis is one of chronic liver diseases which spread in worldwide and it has high risk to turn advanced cirrhosis and hepatocellualr carcinoma. Brassica family has been produced for commercial purpose and in Korea Brassica rapa (Turnip) is cultivated in Ganghwa County, Gyeonggi-do Korea and used for making Kimchi. Recently pharmacological effects of turnip have been known; diabete mellitus modulation, alcohol oxidization, and fibrosis inhibition. In previous study we found antifibrogenic effect of turnip water extract and in this study we made turnip nanoparticle to promote turnip delivery into liver. At the same time we assessed the biological safety of turnip nanoparticle. Thioacetamide (TAA) induced hepatic nodular formation and fibrosis (mean of fibrosis score: 4). However, 1 % turnip nanoparticle inhibited TAA-induced hepatic nodular formation and fibrosis (mean of fibrosis score: 2-3). Activities of serum enzymes (aspartic acid trainsaminase (AST), alanine transaminase (ALT), and total bilirubin (T-Bil)), complete blood count (CBC), and the appearance of organs were not different from control and 1 % turnip nanoparticle treatment. Conclusively 1 % turnip nanoparticle significantly reduced TAA-induced hepatic fibrosis and was safe in 7-weeks feeding.
ISSN
1738-642X
Language
English
URI
http://hdl.handle.net/10371/77743
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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