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Differences in Lipid Peroxidation and Cu,Zn-Superoxide Dismutase in the Hippocampal CA1 Region Between Adult and Aged Dogs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Yoo, Ki-Yeon | - |
dc.contributor.author | Li, Hua | - |
dc.contributor.author | Choi, Jung Hoon | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Sung, Je Kyeong | - |
dc.contributor.author | Lee, In Se | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.date.accessioned | 2009-08-25T07:39:48Z | - |
dc.date.available | 2009-08-25T07:39:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | J. Vet. Med. Sci. 70: 273-277 | en |
dc.identifier.issn | 0916-7250 (print) | - |
dc.identifier.issn | 1347-7439 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/7782 | - |
dc.description.abstract | Reactive oxygen species have been long associated with oxidative stress relevant to many pathological damages. In brain, 4-hydroxy-2E-nonenal (HNE), a major cytotoxic end product of lipid peroxidation, is produced. In contrast, superoxide dismutase (SOD), one of the major antioxidant enzymes, protects neurons from oxidative stress. The aim of this study is to observe differences in the distribution of HNE and Cu,Zn-superoxide dismutase (SOD1) in the hippocampal CA1 region of adult (2-3 years of age) and aged (10-12 years of age) dogs. The HNE immunoreactivity and protein level in the CA1 region were significantly high in the aged dogs compared to those in the adult dogs. SOD1 immunoreactivity and its protein level were also higher in the aged dogs than those in the adult dogs. However, there were not significant differences in NeuN (a neuron-specific soluble nuclear antigen) immunoreactivity in CA1 neurons between the adult and aged dogs. These differences may be associated with oxidative stress in aged dogs compared to that in adult dogs. | en |
dc.description.sponsorship | The authors would like to
thank Mr. Seok Han, Mr. Seung Uk Lee and Ms. Hyun Sook Kim for their technical help in this study. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A050742). | en |
dc.language.iso | en | en |
dc.publisher | Japanese Society of Veterinary Science | en |
dc.subject | adult and aged dog | en |
dc.subject | Cu | en |
dc.subject | Zn-superoxide dismutase | en |
dc.subject | hippocampal CA1 region | en |
dc.subject | lipid peroxidation | en |
dc.title | Differences in Lipid Peroxidation and Cu,Zn-Superoxide Dismutase in the Hippocampal CA1 Region Between Adult and Aged Dogs | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.contributor.AlternativeAuthor | 윤여성 | - |
dc.contributor.AlternativeAuthor | 유기연 | - |
dc.contributor.AlternativeAuthor | 이화 | - |
dc.contributor.AlternativeAuthor | 최정훈 | - |
dc.contributor.AlternativeAuthor | 김대원 | - |
dc.contributor.AlternativeAuthor | 이순신 | - |
dc.contributor.AlternativeAuthor | 성제경 | - |
dc.contributor.AlternativeAuthor | 이인세 | - |
dc.contributor.AlternativeAuthor | 원무호 | - |
dc.identifier.doi | 10.1292/jvms.70.273 | - |
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