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The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer

Cited 52 time in Web of Science Cited 56 time in Scopus
Authors

Park, So Yeon; Kim, Ku Sang; Lee, Taek-Gu; Park, Sung-Shin; Han, Wonshik; Kim, Sung-Won; Noh, Dong-Young; Kim, Sun Mi

Issue Date
2009-02
Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
Citation
AMERICAN JOURNAL OF SURGERY; Vol.197(2); 266-269
Keywords
Core biopsyHistologic gradeEstrogen receptorHER-2Progesterone receptor
Abstract
BACKGROUND: Proper determination of histologic type and biomarkers in a core biopsy specimen is important before preoperative systemic therapy. The purpose of this study was to determine the accuracy of preoperative core biopsy through comparative analysis of histologic grade (HG), hormone receptors, and human epidermal growth factor receptor 2 (HER-2) status in both the core biopsy and surgical specimens. METHODS: We identified 104 patients with invasive ductal cancer who underwent core biopsy and definitive surgery in our institution. The histologic type, HG, estrogen receptor (ER), progesterone receptor (PR), and HER-2 status were determined in both the core biopsy and surgical specimens by one pathologist. RESULTS: The mean age of the 104 patients was 50 +/- 9.9 years and the mean number of core biopsies was 5.1.9. The concordance rates for histologic type, HG, ER, PR, and HER-2 status were 100%, 80.8%, 99%, 97.1%, and 86.5%, respectively. CONCLUSIONS: Core biopsy can predict histologic type, HG, ER, PR and HER-2 status preoperatively in breast cancer when used properly.
ISSN
0002-9610
Language
English
URI
https://hdl.handle.net/10371/77848
DOI
https://doi.org/10.1016/j.amjsurg.2007.11.024
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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