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SERS decoding of micro gold shells moving in microfluidic systems

Cited 19 time in Web of Science Cited 17 time in Scopus
Authors

Lee, Saram; Joo, Segyeong; Park, Sejin; Kim, Soyoun; Chung, Taek Dong; Kim, Hee Chan

Issue Date
2010-05
Publisher
WILEY-V C H VERLAG GMBH
Citation
ELECTROPHORESIS; Vol.31 10; 1623-1629
Keywords
DecodingSurface-enhanced Raman scatteringMicro gold shellFluidic conditionMicrofluidic chip
Abstract
In this study, in situ surface-enhanced Raman scattering (SERS) decoding was demonstrated in microfluidic chips using novel thin micro gold shells modified with Raman tags. The micro gold shells were fabricated using electroless gold plating on PMMA beads with diameter of 15 pm. These shells were sophisticatedly optimized to produce the maximum SERS intensity, which minimized the exposure time for quick and safe decoding. The shell surfaces produced well-defined SERS spectra even at an extremely short exposure time, 1 ms, for a single micro gold shell combined with Raman tags such as 2-naphthalenethiol and benzenethiol. The consecutive SERS spectra from a variety of combinations of Raman tags were successfully acquired from the micro gold shells moving in 25 pm deep and 75 pm wide channels on a glass microfluidic chip. The proposed functionalized micro gold shells exhibited the potential of an on-chip microfluidic SERS decoding strategy for micro suspension array.
ISSN
0173-0835
Language
English
URI
https://hdl.handle.net/10371/77896
DOI
https://doi.org/10.1002/elps.200900743
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College of Medicine/School of Medicine (의과대학/대학원)Biomedical Engineering (의공학전공)Journal Papers (저널논문_의공학전공)
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