Browse

Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow

Cited 73 time in Web of Science Cited 75 time in Scopus
Authors
Cho, Kyung-Ah; Ju, Sun-Young; Cho, Su Jin; Jung, Yun-Jae; Seoh, Ju-Young; Ryu, Kyung-Ha; Han, Ho-Seong; Woo, So-Youn
Issue Date
2009-07
Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation
CELL BIOLOGY INTERNATIONAL; Vol.33(7); 772-777
Keywords
Mesenchymal stem cells (MSCs)Liver injuryTransplantation
Abstract
We have previously reported that bone marrow cells (BMCs) participate in the regeneration after liver injury. However, it is not established that this is the result of differentiation of hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) or the combination of both. We investigated the contribution of each cell fraction to the regenerative process. First, we confirmed that transplanted stem cells migrate directly to injured liver tissue without dispersing to other organs. Next, we divided green fluorescent protein (GFP)-expressing BMCs into three populations as mononuclear cells, MSCs and HSCs. We then compared the engraftment capacity after transplantation of each fraction of cells into liver-injured mice. Of these, the MSCs transplanted group showed the highest GFP fluorescence intensities in liver tissue by flow cytometry analysis and confocal microscopic observation. Furthermore, MSCs showed differentiation potential into hepatocytes when co-cultured with injured liver cells, which suggests that MSCs showed highest potential for the regeneration of injured liver tissue compared with those of the other two cell refractions. (c) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
ISSN
1065-6995
Language
English
URI
http://hdl.handle.net/10371/77898
DOI
https://doi.org/10.1016/j.cellbi.2009.04.023
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse