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Influence of Preoperative Chemoradiotherapy on the Number of Lymph Nodes Retrieved in Rectal Cancer

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dc.contributor.authorHa, Yun Hyung-
dc.contributor.authorJeong, Seung-Yong-
dc.contributor.authorLim, Seok-Byung-
dc.contributor.authorChoi, Hyo Seong-
dc.contributor.authorChang, Hee Jin-
dc.contributor.authorJung, Kyung Hae-
dc.contributor.authorPark, Jae-Gahb-
dc.contributor.authorKim, Dae Yong-
dc.contributor.authorHong, Yong Sang-
dc.date.accessioned2012-06-29T06:55:00Z-
dc.date.available2012-06-29T06:55:00Z-
dc.date.issued2010-08-
dc.identifier.citationANNALS OF SURGERY; Vol.252(2); 336-340ko_KR
dc.identifier.issn0003-4932-
dc.identifier.urihttp://hdl.handle.net/10371/77973-
dc.description.abstractObjective: To evaluate the relation of preoperative chemoradiotherapy to the number of lymph nodes retrieved in curative intent surgery for rectal cancer. Summary Background Data: Current guidelines recommend evaluation of least 12 to 14 lymph nodes in rectal cancer. It is well known that lymph nodes retrieval is affected by many factors. Methods: This was a retrospective study of 615 patients who underwent curative intent surgery for primary rectal cancer. Preoperative chemoradiotherapy involving 50.4 Gy fractionated radiotherapy and concurrent chemotherapy was performed in patients with locally advanced rectal cancer (clinically T3 or T4). We explored associations between the number of lymph nodes retrieved in the pathologic specimen and patient demographics (age, gender, body mass index [BMI]), treatment (surgeon, sphincter-saving, preoperative chemoradiotherapy), and tumor-related variables (location, stage, histology). After adjustment for other factors, we compared the mean number of obtained lymph nodes between patients treated with preoperative chemoradiotherapy and those treated without preoperative chemoradiotherapy. Results: Univariate analysis demonstrated that age, BMI, preoperative chemoradiotherapy, location, and stage significantly related the number of lymph nodes retrieved. Multivariate analysis revealed age, BMI, preoperative chemoradiotherapy, and stage as independent factors influencing the number of lymph nodes retrieved. The mean number of lymph nodes adjusted for age, BMI, and stage was significantly lower in patients treated with preoperative chemoradiotherapy than in those treated without preoperative chemoradiotherapy (14.5 vs. 21.5, P < 0.001). The reduction rate by preoperative chemoradiotherapy was 32.6% (7/21.5). In patients who underwent preoperative chemoradiotherapy, advanced age (P < 0.001) and high BMI (P = 0.037) were associated with decreased number of retrieved lymph nodes. Conclusions: Preoperative chemoradiotherapy significantly decreased the number of retrieved lymph nodes by approximately 33%. Therefore, the recommended number of retrieved lymph nodes should be adjusted when rectal cancer is treated with preoperative chemoradiotherapy.ko_KR
dc.description.sponsorshipSupported by National Cancer Center (grant 0610280).ko_KR
dc.language.isoenko_KR
dc.publisherLIPPINCOTT WILLIAMS & WILKINSko_KR
dc.titleInfluence of Preoperative Chemoradiotherapy on the Number of Lymph Nodes Retrieved in Rectal Cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor하윤형-
dc.contributor.AlternativeAuthor정승용-
dc.contributor.AlternativeAuthor임석병-
dc.contributor.AlternativeAuthor최효성-
dc.contributor.AlternativeAuthor홍용상-
dc.contributor.AlternativeAuthor장희진-
dc.contributor.AlternativeAuthor김대용-
dc.contributor.AlternativeAuthor정경해-
dc.contributor.AlternativeAuthor박재갑-
dc.identifier.doi10.1097/SLA.0b013e3181e61e33-
dc.citation.journaltitleANNALS OF SURGERY-
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dc.description.tc8-
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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