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Characterization of molecular subtypes of Korean breast cancer: An ethnically and clinically distinct population

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dc.contributor.authorHan, Wonshik-
dc.contributor.authorNicolau, Monica-
dc.contributor.authorNoh, Dong-Young-
dc.contributor.authorJeffrey, Stefanie S.-
dc.date.accessioned2012-06-29T08:09:25Z-
dc.date.available2012-06-29T08:09:25Z-
dc.date.issued2010-07-
dc.identifier.citationINTERNATIONAL JOURNAL OF ONCOLOGY; Vol.37, no.1; 51-59ko_KR
dc.identifier.issn1019-6439-
dc.identifier.urihttp://hdl.handle.net/10371/77983-
dc.description.abstractWe aimed to investigate the molecular characteristics of Korean breast cancer. A cDNA microarray study (>42k clones) was performed on 69 breast cancers and three normal breast tissues. The subjects had a high percentage of HER-2 expression, hormone receptor negativity, and young onset. Molecular subtypes according to gene expression profiles were determined and their correlations to the clinicopathologic characteristics and patients outcome were analyzed. The tumors were subdivided into luminal-, normal breast-like, ERBB2(+), and basal-like subtypes according to the correlations to the previously described intrinsic genes and five centroids. Only a few tumors were highly correlated to the luminal B and normal-like centroids. The high grade tumors with high p53 and Ki-67 were found more commonly in non-luminal tumors. Distant recurrence-free survival was worse in ERBB2(+) and basal-like subgroups than luminal tumors. In an unsupervised clustering, with 864 genes, many interesting gene clusters were observed, some of which had not been previously described. Although the Korean breast cancers showed generally similar molecular phenotypes as Western studies, some distinct gene expression patterns and their association to clinical outcomes were observed.ko_KR
dc.language.isoenko_KR
dc.publisherSPANDIDOS PUBL LTDko_KR
dc.subjectbreast neoplasmsko_KR
dc.subjectraceko_KR
dc.subjectAsianko_KR
dc.subjectgene expression profilingko_KR
dc.subjectprognosisko_KR
dc.titleCharacterization of molecular subtypes of Korean breast cancer: An ethnically and clinically distinct populationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor한원식-
dc.contributor.AlternativeAuthor노동영-
dc.identifier.doi10.3892/ijo_00000652-
dc.citation.journaltitleINTERNATIONAL JOURNAL OF ONCOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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