유방 피부에 발생한 이소성 유방외 파젯병 1예

Abstract

Whereas extramammary Paget`s disease commonly occurs in the apocrine gland rich skin areas, ectopic extramammary Paget`s disease develops in the skin areas that are devoid of apocrine glands. We experienced the case of a 34 year-old female patient who had a skin lesion in the upper outer quadrant of the right breast for 5 years and that lesion was diagnosed as Paget`s disease according to the punch biopsy. There was no other underlying malignancy, and so wide excision was performed. The final pathologic diagnosis was Paget`s disease confined to the epidermis and the size of the tumor was 3.0 x 1.1 cm. Positive staining for cytokeratin 7, epithelial membrane antigen and negative staining for S-100 protein and HMB-45 was observed on the immunohistochemical tests. We report here on an extremely unusual case of ectopic extramammary Paget`s disease of the breast skin, and we include a review of the relevant literature.