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Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis
DC Field | Value | Language |
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dc.contributor.author | Kwon, Woon Yong | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Kim, Kyuseok | - |
dc.contributor.author | Jung, Sung Koo | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.date.accessioned | 2012-07-02T01:59:17Z | - |
dc.date.available | 2012-07-02T01:59:17Z | - |
dc.date.issued | 2010-03-28 | - |
dc.identifier.citation | BRITISH JOURNAL OF NUTRITION; Vol.103 6; 890-898 | ko_KR |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78048 | - |
dc.description.abstract | Heat shock protein 70 (HSP70) is reported as the main factor responsible for the beneficial effects of glutamine (GLN) and as a negative regulator of high mobility group box protein-1 (HMGB-1) expression. Our aim was to determine whether GLN attenuates acute lung injury (ALI) by the inhibition of HMGB-1 expression during sepsis. Male Sprague Dawley rats were subjected to caecal ligation and puncture (CLP) to induce sepsis. GLN or saline was administered through tail vein 1 h after CLP. Then, quercetin (Q), an inhibitor of HSP70, was utilised to assess the role of the enhanced HSP70. We observed the survival of the subjects. At 24h post-CLP, we measured lung HSP70, phosphorylated heat shock factor-1 (HSF-1-p) and HMGB-1 expressions, NF-kappa B DNA-binding activity and ALI occurrence. We also measured serum HSP70, IL-6 and HMGB-1 concentrations. GLN improved survival during sepsis. In GLN-treated rats, lung HSP70 and HSF-1-p expressions were enhanced, lung HMGB-1 expression and NF-kappa B DNA-binding activity were suppressed, and ALI was attenuated. Furthermore, in GLN-administered rats, serum HSP70 concentration was higher, and serum IL-6 and HMGB-1 concentrations were lower than those in non-treated rats. Q inhibited the enhancement of HSP70 and HSF-1-p expressions and abrogated the GLN-mediated benefits. In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | CAMBRIDGE UNIV PRESS | ko_KR |
dc.subject | Glutamine | ko_KR |
dc.subject | High mobility group box protein-1 | ko_KR |
dc.subject | Lung injury | ko_KR |
dc.subject | Sepsis | ko_KR |
dc.title | Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 권운용 | - |
dc.contributor.AlternativeAuthor | 서길준 | - |
dc.contributor.AlternativeAuthor | 김경수 | - |
dc.contributor.AlternativeAuthor | 조유환 | - |
dc.contributor.AlternativeAuthor | 이재혁 | - |
dc.contributor.AlternativeAuthor | 김규석 | - |
dc.contributor.AlternativeAuthor | 정성구 | - |
dc.identifier.doi | 10.1017/S0007114509992509 | - |
dc.citation.journaltitle | BRITISH JOURNAL OF NUTRITION | - |
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