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Multiphasic MDCT Enhancement Pattern of Hepatocellular Carcinoma Smaller Than 3 cm in Diameter: Tumor Size and Cellular Differentiation
Cited 92 time in
Web of Science
Cited 98 time in Scopus
- Authors
- Issue Date
- 2009-12
- Publisher
- AMER ROENTGEN RAY SOC
- Citation
- AMERICAN JOURNAL OF ROENTGENOLOGY; Vol.193 6; W482-W489
- Keywords
- enhancement pattern ; hepatocellular carcinoma ; MDCT
- Abstract
- OBJECTIVE. The purpose of this study was to evaluate according to size and degree of cellular differentiation the multiphasic MDCT enhancement pattern of hepatocellular carcinoma (HCC) smaller than 3 cm in diameter in patients with cirrhosis. MATERIALS AND METHODS. In 155 consecutively registered patients (126 men, 29 women; mean age, 58.4 years), 204 pathologically proven HCCs smaller than 3 cm were detected at multiphasic MDCT. Three radiologists in consensus classified the relative attenuation of the tumors compared with the surrounding liver parenchyma as hyperattenuation, isoattenuation, or hypoattenuation on biphasic (n = 86) and triphasic (n = 69) CT scans. RESULTS. The prevalent enhancement patterns of HCC differed depending on tumor size. The prevalent pattern of HCC measuring 20-29 mm was arterial hyperattenuation with venous washout (47%, 47/101). The prevalent enhancement patterns of HCC smaller than 10 mm and HCC measuring 10-19 mm were isoattenuation during the arterial and portal venous phases (29%, 6/21) and hyperattenuation and isoattenuation during the arterial and portal venous phases (33%, 27/82). The typical HCC enhancement pattern (arterial hyperattenuation with venous washout) was identified in 48% (67/141) of the moderately and poorly differentiated HCCs and in 13% (8/63) of well-differentiated HCCs. CONCLUSION. The prevalent enhancement patterns of HCC smaller than 3 cm on multiphasic MDCT scans differed depending on tumor size and cellular differentiation. HCCs smaller than 2 cm and well-differentiated HCCs frequently had atypical enhancement patterns.
- ISSN
- 0361-803X
- Language
- English
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