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Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes

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dc.contributor.authorOh, Min-A-
dc.contributor.authorChoi, Suyong-
dc.contributor.authorLee, Mi Ji-
dc.contributor.authorChoi, Moon-Chang-
dc.contributor.authorKo, Wonil-
dc.contributor.authorOh, Eok-Soo-
dc.contributor.authorKim, Sung-Hoon-
dc.contributor.authorLee, Jung Weon-
dc.contributor.authorBuday, Laszlo-
dc.contributor.authorCance, William G.-
dc.contributor.authorLee, Sin-Ae-
dc.date.accessioned2012-07-03T01:15:08Z-
dc.date.available2012-07-03T01:15:08Z-
dc.date.issued2009-05-
dc.identifier.citationBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH; Vol.1793 5; 781-791ko_KR
dc.identifier.issn0167-4889-
dc.identifier.urihttps://hdl.handle.net/10371/78169-
dc.description.abstractCell adhesion to the extracellular matrix (ECM) can activate signaling via focal adhesion kinase (FAK) leading to dynamic regulation of cellular morphology. Mechanistic basis for the lack of effective intracellular signaling by non-attached epithelial cells is poorly understood. To examine whether signaling in suspended cells is regulated by Fer cytoplasmic tyrosine kinase, we investigated the effect of ectopic Fer expression on signaling in suspended or adherent hepatocytes. We found that ectopic Fer expression in Huh7 hepatocytes in suspension or on non-permissive poly-lysine caused significant phosphorylation of FAK Tyr577, Tyr861, or Tyr925, but not Tyr397 or Tyr576. Fer-mediated FAK phosphorylation in suspended cells was independent of c-Src activity or growth factor stimulation, but dependent of cortactin expression. Consistent with these results, complex formation between FAK, Fer, and cortactin was observed in suspended cells. The Fer-mediated effect correlated with multiple membrane protrusions, even on poly-lysine. Together, these observations suggest that Fer may allow a bypass of anchorage-dependency for intracellular signal transduction in hepatocytes. (C) 2009 Elsevier B.V. All rights reserved.ko_KR
dc.description.sponsorshipThis work was supported by the grant funded by the Korea
government [Research Programs for CPMRC, R13-2007-019-00000-0
from Korea Ministry of Education, Science and Technology to S-H Kim,
New Drug Target Discovery, 2007-03536, and Cell Dynamic Research
Center, R11-2007-007-01004-0 to J.W. Lee] and in part by research
grant from Cancer Research Institute, Seoul National University (2007,
to J.W. Lee).		ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectCell adhesionko_KR
dc.subjectFocal adhesion kinaseko_KR
dc.subjectProtein-protein interactionko_KR
dc.subjectCortactinko_KR
dc.subjectFerko_KR
dc.titleSpecific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor오민아-
dc.contributor.AlternativeAuthor최수용-
dc.contributor.AlternativeAuthor이미지-
dc.contributor.AlternativeAuthor최문창-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor고원일-
dc.contributor.AlternativeAuthor오억수-
dc.contributor.AlternativeAuthor김성훈-
dc.contributor.AlternativeAuthor이정원-
dc.identifier.doi10.1016/j.bbamcr.2009.01.015-
dc.citation.journaltitleBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH-
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