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CD4(+)CD25(+) regulatory T cells attenuate hypersensitivity pneumonitis by suppressing IFN-gamma production by CD4(+) and CD8(+) T cells

Cited 19 time in Web of Science Cited 21 time in Scopus
Authors
Park, Yuna; Oh, Sae Jin; Chung, Doo Hyun
Issue Date
2009-12
Publisher
FEDERATION AMER SOC EXP BIOL
Citation
JOURNAL OF LEUKOCYTE BIOLOGY; Vol.86 6; 1427-1437
Keywords
T-reg cellssuppressionSaccharopolyspora rectivirgulaINF-gammaIL-10
Abstract
HP results from the repeated inhalation of environmental antigens; however, the roles of CD4(+)CD25(+) T-reg cells in HP are unknown. Therefore, we investigated the functions of CD4(+)CD25(+) T-reg cells in SR-induced murine HP. More severe HP was observed in CD4(+)CD25(+) T-reg cell-depleted mice than in control mice in terms of histological alterations, inflammatory cell numbers in BALF, and the serum level of SR-specific IgG, which were restored by the adoptive transfer of CD4(+)CD25(+) T-reg cells. The CD4(+)CD25(+) T-reg cell-depleted mice also showed elevated levels of IFN-gamma, TGF-beta, and reduced IL-4 production in the lungs. Moreover, IL-10 production of CD4(+)CD25(+) T-reg cells and direct contact between CD4(+)CD25(+) T-reg cells and CD4(+) or CD8(+) T cells in BALF resulted in reduced IFN-gamma production. Taken together, CD4(+)CD25(+) T-reg cells play a protective role in SR-induced HP by suppressing IFN-gamma production by T cells. J. Leukoc. Biol. 86: 1427-1437; 2009.
ISSN
0741-5400
Language
English
URI
http://hdl.handle.net/10371/78223
DOI
https://doi.org/10.1189/jlb.0908542
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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