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CD4(+)CD25(+) regulatory T cells attenuate hypersensitivity pneumonitis by suppressing IFN-gamma production by CD4(+) and CD8(+) T cells
DC Field | Value | Language |
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dc.contributor.author | Park, Yuna | - |
dc.contributor.author | Oh, Sae Jin | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.date.accessioned | 2012-07-03T05:05:00Z | - |
dc.date.available | 2012-07-03T05:05:00Z | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | JOURNAL OF LEUKOCYTE BIOLOGY; Vol.86 6; 1427-1437 | ko_KR |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78223 | - |
dc.description.abstract | HP results from the repeated inhalation of environmental antigens; however, the roles of CD4(+)CD25(+) T-reg cells in HP are unknown. Therefore, we investigated the functions of CD4(+)CD25(+) T-reg cells in SR-induced murine HP. More severe HP was observed in CD4(+)CD25(+) T-reg cell-depleted mice than in control mice in terms of histological alterations, inflammatory cell numbers in BALF, and the serum level of SR-specific IgG, which were restored by the adoptive transfer of CD4(+)CD25(+) T-reg cells. The CD4(+)CD25(+) T-reg cell-depleted mice also showed elevated levels of IFN-gamma, TGF-beta, and reduced IL-4 production in the lungs. Moreover, IL-10 production of CD4(+)CD25(+) T-reg cells and direct contact between CD4(+)CD25(+) T-reg cells and CD4(+) or CD8(+) T cells in BALF resulted in reduced IFN-gamma production. Taken together, CD4(+)CD25(+) T-reg cells play a protective role in SR-induced HP by suppressing IFN-gamma production by T cells. J. Leukoc. Biol. 86: 1427-1437; 2009. | ko_KR |
dc.description.sponsorship | This study was supported by the Korea Science and Engineering
Foundation through the Tumor Immunity Medical Research Center at Seoul National University College of Medicine and a grant (03-2007-009-0) from the Seoul National University Hospital (SNUH) Research Fund. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | FEDERATION AMER SOC EXP BIOL | ko_KR |
dc.subject | T-reg cells | ko_KR |
dc.subject | suppression | ko_KR |
dc.subject | Saccharopolyspora rectivirgula | ko_KR |
dc.subject | INF-gamma | ko_KR |
dc.subject | IL-10 | ko_KR |
dc.title | CD4(+)CD25(+) regulatory T cells attenuate hypersensitivity pneumonitis by suppressing IFN-gamma production by CD4(+) and CD8(+) T cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박유나 | - |
dc.contributor.AlternativeAuthor | 오세진 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.identifier.doi | 10.1189/jlb.0908542 | - |
dc.citation.journaltitle | JOURNAL OF LEUKOCYTE BIOLOGY | - |
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dc.description.tc | 8 | - |
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