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High-Throughput Integrated Analyses for the Tyrosinase-Induced Melanogenesis: Microarray, Proteomics and Interactomics Studies

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dc.contributor.authorLue, Zhi-Rong-
dc.contributor.authorSeo, Eunyoung-
dc.contributor.authorYan, Li-
dc.contributor.authorYin, Shang-Jun-
dc.contributor.authorQian, Guo-Ying-
dc.contributor.authorYang, Jun-Mo-
dc.contributor.authorPark, Yong-Doo-
dc.contributor.authorSi, Yue-Xiu-
dc.date.accessioned2012-07-03T07:58:54Z-
dc.date.available2012-07-03T07:58:54Z-
dc.date.issued2010-10-
dc.identifier.citationJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS; Vol.28, no.2; 259-276ko_KR
dc.identifier.issn0739-1102-
dc.identifier.urihttp://hdl.handle.net/10371/78299-
dc.description.abstractThe tyrosinase gene was overexpressed in HEK293 cells, and then a DNA microarray and proteomic tools were applied to detect the dysregulated genes in highly pigmented cells. The candidate genes from the microarray were compared to the yeast two-hybridization results. Computational prediction via protein-protein interaction mapping suggested the existence of 66 hub genes in melanogenesis. Most importantly, RNA binding motif protein 9 is newly detected as a putative critical melanogenesis-associated gene in this study. The approach of combining the expression data analysis and predicted protein interaction partners performed in large scales can bring more reliable gene targets for understanding pigmentation.ko_KR
dc.language.isoenko_KR
dc.publisherADENINE PRESSko_KR
dc.subjectTyrosinaseko_KR
dc.subjectProteomicsko_KR
dc.subjectInteractomicsko_KR
dc.subjectMicroarrayko_KR
dc.subjectMelanogenesisko_KR
dc.titleHigh-Throughput Integrated Analyses for the Tyrosinase-Induced Melanogenesis: Microarray, Proteomics and Interactomics Studiesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor서은영-
dc.contributor.AlternativeAuthor박용두-
dc.contributor.AlternativeAuthor양준모-
dc.citation.journaltitleJOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS-
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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