Browse

Intra-operative sentinel lymph node identification using a novel receptor-binding agent (technetium-99m neomannosyl human serum albumin, 99mTc-MSA) in stage I non-small cell lung cancer

DC Field Value Language
dc.contributor.authorKim, Sungeun-
dc.contributor.authorKim, Hyun Koo-
dc.contributor.authorKang, Du-Young-
dc.contributor.authorJeong, Jae Min-
dc.contributor.authorChoi, Young Ho-
dc.date.accessioned2012-07-03T08:38:43Z-
dc.date.available2012-07-03T08:38:43Z-
dc.date.issued2010-06-
dc.identifier.citationEUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY; Vol.37 6; 1450-1456ko_KR
dc.identifier.issn1010-7940-
dc.identifier.urihttp://hdl.handle.net/10371/78318-
dc.description.abstractObjective: In the previous report, to simplify the synthesis and labelling procedures and to improve the biological properties, we developed a novel mannose receptor-binding agent, technetium-99m human serum albumin (99mTc-MSA), for sentinel lymph node detection. This study is the first clinical trial designed to test the reliability and feasibility of sentinel node detection using this new radioactive agent in patients with stage I non-small cell lung cancer. Methods: Forty-two patients (30 men, 12 women; mean age 63.3 +/- 8.9 years) that were candidates for lobectomy with mediastinal lymph node dissection for stage I non-small cell lung cancer were enrolled. A total dose of 1 mCi of 99mTc-MSA in 0.2 ml was administered in one shot at the peritumoural region approximately 3 h before surgery. The radioactivity in the lymph nodes was counted before (in vivo) and after (ex vivo) dissection with a hand-held gamma probe. A sentinel lymph node was defined as any node for which the radioactivity count was 5 times that of the resected lung tissue with the lowest count for the ex vivo counts. All harvested lymph nodes were cut into 2-mm slices and ultimately diagnosed by using formalin-fixed and paraffin-embedded sections with haematoxylin and eosin staining. Results: 99mTc-MSA was taken up by the lymph nodes and its detection did not change until 21 h after the injection. The number of dissected lymph nodes per patient was 22.1 +/- 11.6 (range 4-57). Among 42 patients, the sentinel lymph nodes could be identified in 40 patients (95.2%). The number of sentinel lymph nodes identified was 2.3 +/- 1.1 stations (range 1-5) per patient. Ten out of 40 patients (25.0%) had metastases in 11 sentinel lymph nodes. Three of these 11 sentinel lymph nodes (27.3%) had skip metastases. No false-negative sentinel lymph nodes were detected in any of the 10 patients with N1 or N2 disease (0%). The relationship between in vivo and ex vivo results for mediastinal sentinel lymph nodes showed concurrence in 29 out of 40 patients (72.5%). Conclusions: Intra-operative sentinel lymph node identification using 99mTc-MSA appears to be feasible and reliable in stage I non-small cell lung cancer. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.ko_KR
dc.description.sponsorshipThis study was supported by a grant of the Korean Health Technology R&D
Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea.
(A070001)
ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectLung cancerko_KR
dc.subjectMediastinal lymph node dissectionko_KR
dc.subjectSentinel lymph nodeko_KR
dc.subjectLobectomyko_KR
dc.titleIntra-operative sentinel lymph node identification using a novel receptor-binding agent (technetium-99m neomannosyl human serum albumin, 99mTc-MSA) in stage I non-small cell lung cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김성은-
dc.contributor.AlternativeAuthor김현구-
dc.contributor.AlternativeAuthor강두영-
dc.contributor.AlternativeAuthor정재민-
dc.contributor.AlternativeAuthor최영호-
dc.identifier.doi10.1016/j.ejcts.2010.01.012-
dc.citation.journaltitleEUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY-
dc.description.citedreferenceNomori H, 2009, ANN THORAC SURG, V87, P906, DOI 10.1016/j.athoracsur.2008.12.070-
dc.description.citedreferenceNomori H, 2007, J THORAC CARDIOV SUR, V133, P780, DOI 10.1016/j.jtcvs.2006.10.027-
dc.description.citedreferenceSchirren J, 2006, THORAC CARDIOV SURG, V54, P373, DOI 10.1055/s-2006-924194-
dc.description.citedreferenceRzyman W, 2006, ANN THORAC SURG, V82, P237, DOI 10.1016/j.athoracsur.2006.01.094-
dc.description.citedreferenceNOMORI H, 2006, ANN THORAC CARDIOVAS, V12, P83-
dc.description.citedreferenceAtinkaya C, 2005, NUCL MED COMMUN, V26, P717-
dc.description.citedreferenceJeong JM, 2004, NUCL MED COMMUN, V25, P1211-
dc.description.citedreferenceNomori H, 2004, LUNG CANCER-J IASLC, V46, P49, DOI 10.1016/j.lungcan.2004.03.008-
dc.description.citedreferenceTakagi K, 2004, NUCL MED BIOL, V31, P893, DOI 10.1016/j.nucmedbio.2004.04.008-
dc.description.citedreferenceLardinois D, 2003, EUR J CARDIO-THORAC, V23, P824, DOI 10.1016/S1010-7940(03)00077-0-
dc.description.citedreferenceMelfi FMA, 2003, EUR J CARDIO-THORAC, V23, P214, DOI 10.1016/S1010-7940(02)00763-7-
dc.description.citedreferenceSugi K, 2003, LUNG CANCER-J IASLC, V39, P37-
dc.description.citedreferenceNomori H, 2002, J THORAC CARDIOV SUR, V124, P486, DOI 10.1067/mtc.2002.124496-
dc.description.citedreferenceJinno H, 2002, BIOMED PHARMACOTHER, V56, p213S-
dc.description.citedreferenceHodgson N, 2001, ANN SURG ONCOL, V8, P133-
dc.description.citedreferenceLiptay MJ, 2000, ANN THORAC SURG, V70, P384-
dc.description.citedreferenceDeschamps C, 2000, ANN THORAC SURG, V70, P389-
dc.description.citedreferenceNaruke T, 1999, EUR J CARDIO-THORAC, V16, pS17-
dc.description.citedreferenceOkada M, 1999, J THORAC CARDIOV SUR, V118, P270-
dc.description.citedreferenceAsamura H, 1999, J THORAC CARDIOV SUR, V117, P1102-
dc.description.citedreferenceTANITA T, 1999, JPN J THORAC CARDIOV, V47, P253-
dc.description.citedreferenceVera DR, 1997, J NUCL MED, V38, P530-
dc.description.citedreferenceHATA E, 1994, KYOBU GEKA, V47, P40-
dc.description.citedreferenceHE XM, 1992, NATURE, V358, P209-
dc.description.citedreferenceRIQUET M, 1989, J THORAC CARDIOV SUR, V97, P623-
dc.description.citedreferenceHENZE E, 1982, J NUCL MED, V23, P923-
dc.description.tc3-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse