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Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: A randomized, double-blind, placebo-controlled, phase III study

Cited 54 time in Web of Science Cited 64 time in Scopus
Authors
Eun, Hee Chul; Kwon, Oh Sang; Yeon, Je Ho; Shin, Hyo Seung; Ro, Byung In; Sim, Woo Young; Lee, Won-Soo; Hong, Seung Phil; Ji, Jae Hong; Park, Hwa Young; Lew, Bark Lynn; Cho, Han Kyong; Kim, Byung Yoon
Issue Date
2010-08
Publisher
MOSBY-ELSEVIER
Citation
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY; Vol.63(2); 252-258
Keywords
androgenetic alopeciadutasteridetreatmentmale pattern hair loss
Abstract
Background: Dutasteride (Avodart) is a dual inhibitor of both type I and type II 5 alpha reductases, and thus inhibits conversion of testosterone to dihydrotestosterone, a key mediator of male pattern hair loss. Objectives: The aim of this randomized double-blind phase III study was to compare the efficacy, safety, and tolerability of dutasteride (0.5 mg) and placebo for 6 months of treatment in male patients with male pattern hair loss. Methods: A total of 153 men, 18 to 49 years old, were randomized to receive 0.5 mg of dutasteride or placebo daily for 6 months. Efficacy was evaluated by the change of hair counts, subject assessment, and photographic assessment by investigators and panels. Results: Mean change of hair counts from baseline to 6 months after treatment start was an increase of 12.2/cm(2) in dutasteride group and 4.7/cm(2) in placebo group and this difference was statistically significant (P = .0319). Dutasteride showed significantly higher efficacy than placebo group by subject self-assessment and by investigator and panel photographic assessment. There was no major difference in adverse events between two groups. Limitations: The study was limited to 6 months. Conclusions: This study clearly showed that 0.5 mg of dutasteride improved hair growth and was relatively well tolerated for the treatment of male pattern hair loss.
ISSN
0190-9622
Language
English
URI
http://hdl.handle.net/10371/78325
DOI
https://doi.org/10.1016/j.jaad.2009.09.018
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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