Browse

Erythrocyte Malondialdehyde and Glutathione Levels in Vitiligo Patients

Cited 11 time in Web of Science Cited 19 time in Scopus
Authors
Shin, Jung Won; Nam, Kyung Mi; Choi, Hye Ryung; Huh, Sun Young; Youn, Sang Woong; Park, Kyoung Chan; Huh, Chang Hun; Kim, Shin Woo
Issue Date
2010-08
Publisher
KOREAN DERMATOLOGICAL ASSOC
Citation
ANNALS OF DERMATOLOGY; Vol.22, no.3; 279-283
Keywords
ErythrocyteGlutathioneMalondialdehydeVitiligoSmoking
Abstract
Background: Vitiligo is an acquired and progressive hypomelanotic disease that manifests as circumscribed depigmented patches on the skin. Although the precise mechanism remains to be elucidated, an imbalance of the oxidant/antioxidant system has been proposed as an important etiologic mechanism. Objective: The objective of this study was to evaluate the oxidant/antioxidant status of vitiligo patients at the erythrocyte level. Methods: Fifty-three vitiligo patients and 65 phototype-, age-, and sex- matched healthy controls were included in this study. Blood samples were collected from all subjects, and all patients were instructed to answer a questionnaire. Results: Erythrocyte levels of malondialdehyde (MDA) and glutathione (GSH) were measured. All patients were told to answer a questionnaire regarding their habitual behavior, including frequency of smoking and type of diet. We observed significantly lower levels of GSH in vitiligo patients, but the levels of MDA did not differ between patients and controls. Vitiligo patients who smoked showed significantly lower GSH levels compared to non-smoking patients, but the levels of MDA were unchanged between the 2 groups. Conclusion: From our results, we conclude that reduced erythrocytic or systemic GSH levels constitute a distinctive feature in vitiligo patients regardless of disease activity.
ISSN
1013-9087
Language
English
URI
http://hdl.handle.net/10371/78331
DOI
https://doi.org/10.5021/ad.2010.22.3.279
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse