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The Effect of Curculigoside on the Expression of Matrix Metalloproteinase-1 in Cultured Human Skin Fibroblasts

Cited 15 time in Web of Science Cited 19 time in Scopus
Authors
Lee, Song-Yi; Kim, Mi-Ran; Choi, Hong Seok; Moon, Hyung-In; Lee, Dong Gun; Woo, Eun-Rhan; Chung, Jin Ho
Issue Date
2009-10
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH; Vol.32 10; 1433-1439
Keywords
Curculigo orchioides G.Matrix metalloproteinase-1Type-1 procollagenCycloartane saponinAmaryllidaceaePhenolic glycosideCurculigoside
Abstract
The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
ISSN
0253-6269
Language
English
URI
http://hdl.handle.net/10371/78336
DOI
https://doi.org/10.1007/s12272-009-2013-4
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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