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Ultraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblasts

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dc.contributor.authorSeo, Jo-Eun-
dc.contributor.authorKim, Sangmin-
dc.contributor.authorShin, Mi Hee-
dc.contributor.authorKim, Mi-Sun-
dc.contributor.authorPark, Chi-Hyun-
dc.contributor.authorChung, Jin Ho-
dc.contributor.authorEun, Hee Chul-
dc.date.accessioned2012-07-04T00:38:05Z-
dc.date.available2012-07-04T00:38:05Z-
dc.date.issued2010-07-
dc.identifier.citationJOURNAL OF DERMATOLOGICAL SCIENCE; Vol.59(1); 16-24ko_KR
dc.identifier.issn0923-1811-
dc.identifier.urihttp://hdl.handle.net/10371/78340-
dc.description.abstractBackground: Thrombospondin-1 (TSP-1) is a matricellular glycoprotein and recognized as an inhibitor of angiogenesis and an activator of transforming growth factor-beta (TGF-beta). Although TSP-1 expression has been shown to be regulated by various stimuli including UV in some types of cell, more work need to be done to understand the regulation of TSP-1 expression and its functional significances in many other types of cell. Objective: In this study, we investigated the effect of UV on TSP-1 expression in human skin dermis and dermal fibroblasts and the role of TSP-1 on the type I procollagen expression after UV exposure. Methods: Human buttock skin and human dermal fibroblasts were irradiated with UV. The mRNA and the protein levels of TSP-1 or type I procollagen were measured by real-time polymerase chain reaction and Western blotting, respectively. Results: We found that UV irradiation increased TSP-1 expression at the mRNA and protein levels in human skin dermis and dermal fibroblasts. UV-induced TSP-1 expression was greatly suppressed by inhibition of the PI3K, Akt, or mTOR pathways. The inhibition of TSP-1 activity by a blocking peptide or suppression of TSP-1 expression by specific TSP-1 small interfering RNA augmented the UV-induced decrease of type I procollagen expression. Conclusion: Our results suggest that UV-induced TSP-1 plays an important role on alleviating and/or recovering the type I procollagen expression downregulated by UV in human dermal fibroblasts.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectUV irradiationko_KR
dc.subjectFibroblastsko_KR
dc.subjectTSP-1ko_KR
dc.subjectProcollagenko_KR
dc.subjectDermisko_KR
dc.titleUltraviolet irradiation induces thrombospondin-1 which attenuates type I procollagen downregulation in human dermal fibroblastsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor서조은-
dc.contributor.AlternativeAuthor김상민-
dc.contributor.AlternativeAuthor신미희-
dc.contributor.AlternativeAuthor김미선-
dc.contributor.AlternativeAuthor은희철-
dc.contributor.AlternativeAuthor박치현-
dc.contributor.AlternativeAuthor정진호-
dc.identifier.doi10.1016/j.jdermsci.2010.04.010-
dc.citation.journaltitleJOURNAL OF DERMATOLOGICAL SCIENCE-
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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