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Differential expression of ABO antigens in normal and altered skin conditions
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- Authors
- Issue Date
- 2010-04
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- JOURNAL OF INVESTIGATIVE DERMATOLOGY; Vol.130 ; S72-S72
- Abstract
- Since its discovery by Karl Landsteiner in 1900, ABO blood group antigens have played a pivotal
role in transfusion medicine. Recently, their possible roles in inflammation and cancer have been
proposed; however, their role in skin remains elusive. To elucidate their expression and function
in skin, semiquantitative immunohistochemical analyses using monoclonal anti-A, B, or, H antibody
were performed for the specimens diagnosed as psoriasis, atopic dermatitis, ichthyosis vulgaris,
cellulitis, and cutaneous lupus erythematosus, and for 2-MED ultraviolet (UV)-irradiated
skin and normal control. In normal skin, A/B antigen was mainly expressed in stratum granulosum,
while H antigen was in stratum spinosum. In psoriasis and atopic dermatitis, A or B antigen expression
showed an appreciable decrease in stratum granulosum with a slight increase in stratum spinosum,
and H antigen was extensively stained in stratum spinosum. Although A/B antigen expression
also decreased in ichthyosis vulgaris, it was not evident as psoriasis or atopic dermatitis. A/B
antigen expression in cellulitis and cutaneous lupus erythematosus decreased in stratum granulosum,
but increased considerably in stratum corneum, stratum spinosum. In UV-irradiated skin, A/B
antigen expression in stratum granulosum were decreased, but H antigen expression showed marked
increase in stratum spinosum and stratum basale. Real-time RT-PCR revealed that transferase A
and B decreased after the UV irradiation, whereas related glycosyltransferase including FUT1,
B4GALT1,2,3,4, B3GNT5, B4GALT6 increased at 24h after the irradiation. In conclusion, the expression
of ABO blood group antigen showed a differential distribution and intensity according to skin
disorders, suggesting that ABO blood groups might be implicated in the pathogenesis of various
skin diseases in the aspect of differentiation and inflammation.
- ISSN
- 0022-202X
- Language
- English
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