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Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder
DC Field | Value | Language |
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dc.contributor.author | Lee, Kyu Young | - |
dc.contributor.author | Song, Joo Yun | - |
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Kim, Seong Chan | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Joo, Eun-Jeong | - |
dc.date.accessioned | 2012-07-04T05:57:49Z | - |
dc.date.available | 2012-07-04T05:57:49Z | - |
dc.date.issued | 2010-10-01 | - |
dc.identifier.citation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 7; 1196-1201 | ko_KR |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78420 | - |
dc.description.abstract | Genes associated with circadian rhythms have been suggested to play an important role in the pathophysiology of bipolar disorder A single nucleotide polymorphism (SNP) in the 3`-flanking region of CLOCK (3111T/C, rs1801260) has been reported to be associated with sleep disturbances and an increased recurrence rate in patients with bipolar disorder. We examined the association of CLOCK 3111T/C with bipolar disorder in 260 patients and 350 controls in a Korean population CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder (P=0.012, P=0 033, respectively) Morningness/eveningness (M/E) was evaluated using the Composite Scale of Morningness (CSM) in 108 patients with bipolar disorder In the subgroup analysis of the highest and lowest 25th percentile of M/E scores, significantly more C allele carriers were found among extreme evening types than among extreme morning types (P= 0.041) After correcting for age. C allele carriers had lower M/E scores than those carrying the T/T genotype, but the association was not statistically significant We also analyzed the association between age at onset (AAO) and CLOCK 3111T/C in the bipolar disorder group, and no association was found Despite the relatively small sample sizes, these results support a possible role of the CLOCK 3111T/C SNP in bipolar disorder. Further studies with larger samples and more polymorphisms are necessary (C) 2010 Elsevier Inc All rights reserved | ko_KR |
dc.description.sponsorship | This research was supported by a grant (A080534) from the Korea
Health 21 R&D project, Ministry for Health, Welfare and Family Affairs, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | ko_KR |
dc.subject | Age at onset | ko_KR |
dc.subject | Morningness/eveningness | ko_KR |
dc.subject | Bipolar disorder | ko_KR |
dc.subject | CLOCK | ko_KR |
dc.subject | Korean | ko_KR |
dc.title | Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이규영 | - |
dc.contributor.AlternativeAuthor | 송주윤 | - |
dc.contributor.AlternativeAuthor | 김세현 | - |
dc.contributor.AlternativeAuthor | 김성찬 | - |
dc.contributor.AlternativeAuthor | 주은정 | - |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.identifier.doi | 10.1016/j.pnpbp.2010.06.010 | - |
dc.citation.journaltitle | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
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dc.description.tc | 6 | - |
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