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Patients taking medications for bipolar disorder are more prone to metabolic syndrome than Korea`s general population

Cited 23 time in Web of Science Cited 26 time in Scopus
Authors
Lee, Nam Young; Kim, Se Hyun; Cho, Belong; Lee, Yeon Ji; Kang, Ung Gu; Ahn, Yong Min; Kim, Yong Sik; Chang, Jae Seung
Issue Date
2010-10-01
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; Vol.34 7; 1243-1249
Keywords
Metabolic syndromeBipolar disorderControl groupIndirectly standardized prevalence ratioCross-sectional
Abstract
Despite growing concerns about the co-morbidity of metabolic syndrome (MetS) and bipolar disorder, few studies have been conducted on this topic in Asian populations This study examined Korean patients with bipolar disorder to assess its co-morbidity with MetS and to compare the prevalence of MetS in patients with medication for bipolar disorder with that of healthy patients We used cross-sectional data from the medical records of patients with bipolar disorder who presented to the psychiatric clinic in Seoul National University Hospital between June 2007 and June 2008. The control group, matched for age and gender, was randomly drawn from visitors to the Health Promotion Center at the same hospital during the same period We compared the prevalence of MetS between these two groups with independent sample t-tests and chi-squared tests We also calculated the indirectly standardized prevalence ratio (ISPR) with a standardization that used the Fourth Korean National Health and Nutrition Examination Survey (KNHNES. 2007) The prevalence of MetS in patients who took medication for bipolar disorder (N = 152) was 270%. 25.0% and 25 7%, based on the definitions of the American Heart Association and the National Heart, Lung and Blood Institute`s adaptation of the Adult Treatment Panel III (AHA), the National Cholesterol Education Program for Adult Treatment Panel III (ATPIII) and the International Diabetes Federation (IDF), respectively The present study determined that the prevalence of MetS was significantly higher in patients with bipolar disorder than in the control group, the odds ratios (OR) (95%CI) were 2.44 (1 35-4 40), 248 (1.34-459) and 257 (1.40-4.74), based on the definition of the ANA. ATPIII and IDF, respectively.The ISPR (95%CI) was 1.48(1 02-1 93), 1.54(1 05-2 03) and 1 98 (1 36-2 60). respectively Patients with medications for bipolar disorder showed a significantly higher prevalence of increased waist circumference, elevated triglycerides. and reduced HDL-cholesterol than the control group. The prevalence of MetS in patients taking medication for bipolar disorder was higher than that in the general population Obesity and dyslipidemia were particularly prevalent in patients with bipolar disorder (C) 2010 Elsevier Inc All rights reserved
ISSN
0278-5846
Language
English
URI
http://hdl.handle.net/10371/78422
DOI
https://doi.org/10.1016/j.pnpbp.2010.06.029
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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