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Clinical and immunologic effects of sublingual immunotherapy on patients with allergic rhinitis to house-dust mites: 1-Year follow-up results

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dc.contributor.authorKim, Seung-Tae-
dc.contributor.authorHan, Doo Hee-
dc.contributor.authorMoon, Il Joon-
dc.contributor.authorLee, Chul Hee-
dc.contributor.authorRhee, Chae-Seo-
dc.contributor.authorMin, Yang-Gi-
dc.date.accessioned2012-07-04T07:49:15Z-
dc.date.available2012-07-04T07:49:15Z-
dc.date.issued2010-08-
dc.identifier.citationAMERICAN JOURNAL OF RHINOLOGY & ALLERGY; Vol.24 4; 271-275ko_KR
dc.identifier.issn1945-8924-
dc.identifier.urihttp://hdl.handle.net/10371/78472-
dc.description.abstractBackground: There have been no data on sublingual immunotherapy (SLIT) in Asian patients with allergic rhinitis (AR) sensitized to house-dust mites (HDMs). This study aimed to investigate the efficacy and immunologic change after 12 months of SLIT in Korean patients. Methods: Fifty-eight patients, who had AR caused by Dermatophagoides pteronyssinus and Dermatophagoides farinae and who completed 12 months of SLIT were included. Symptom scores were evaluated before and after 12 months of SLIT, and medication scores were assessed throughout the study. Peripheral blood eosinophil counts, eosinophil cationic protein (ECP), total IgE, and specific IgE were also evaluated. Results: All of the symptoms of AR were significantly improved with reduced medication scores. In addition, there were significant decrements in peripheral blood eosinophil counts and ECP (p = 0.025 and p = 0.048, respectively). Specific IgE for D. farinae slightly increased (p = 0.019), whereas specific IgE for D. pteronyssinus and total IgE did not change significantly. Thirty-six (62%) of 58 patients were in the effective response group. Although not statistically significant, findings in the study showed that the effective response group had a tendency to have lug-her ECP levels before SLIT than the ineffective response group (p = 0.056). Conclusion: SLIT improved the symptoms and medication scores in Korean patients with AR from HDM. Laboratory parameters including eosinophil counts, ECP, and specific IgE for D. farinae seemed to be modified after 1-year SLIT. A high ECP level may be a useful parameter to predict the effectiveness of SLIT and select the patient for the treatment. (Am J Rhinol Allergy 24, 271-275, 2010; doi: 10.2500/ajra.2010.24.3501)ko_KR
dc.language.isoenko_KR
dc.publisherOCEAN SIDE PUBLICATIONS INCko_KR
dc.subjectAllergic rhinitisko_KR
dc.subjectefficacyko_KR
dc.subjecthouse dust mitesko_KR
dc.subjectsublingual immunotherapyko_KR
dc.subjectpatient selectionko_KR
dc.subjecteosinophil cationic proteinko_KR
dc.subjectDermatophagoides pteronyssinusko_KR
dc.subjectAsianko_KR
dc.subjectDermatophagoides farinaeko_KR
dc.titleClinical and immunologic effects of sublingual immunotherapy on patients with allergic rhinitis to house-dust mites: 1-Year follow-up resultsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김승태-
dc.contributor.AlternativeAuthor한두희-
dc.contributor.AlternativeAuthor문일준-
dc.contributor.AlternativeAuthor이철희-
dc.contributor.AlternativeAuthor민양기-
dc.contributor.AlternativeAuthor이재서-
dc.identifier.doi10.2500/ajra.2010.24.3501-
dc.citation.journaltitleAMERICAN JOURNAL OF RHINOLOGY & ALLERGY-
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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