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The Replication of Egr3 as a Potential Susceptibility Gene for Schizophrenia in Korean Patients with Schizophrenia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Se Hyun | - |
dc.contributor.author | Song, Joo Yun | - |
dc.contributor.author | Joo, Eun-Jeong | - |
dc.contributor.author | Lee, Kyu Young | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.date.accessioned | 2012-07-04T08:23:51Z | - |
dc.date.available | 2012-07-04T08:23:51Z | - |
dc.date.issued | 2010-05-01 | - |
dc.identifier.citation | BIOLOGICAL PSYCHIATRY; Vol.67 9; 164S-164S | ko_KR |
dc.identifier.issn | 0006-3223 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78481 | - |
dc.description.abstract | Background: Early growth response (Egr) genes play critical role in signal
transduction in the brain, which is involved in neuronal activation, brain development, and synaptic plasticity. Egr3, a member of Egr gene family, resides at the chromosomal location 8p21.3 and was suggested as a potential susceptibility gene in schizophrenia from study with Japanese population, which requires further replication with an independent sample. Methods: We investigated the association of Egr3 and Egr2 genes with schizophrenia in Korean patients with schizophrenia. Along with 350 healthy individuals, a sample of 244 schizophrenia was analyzed. Results: Among examined four SNPs of Egr3, SNP3 in the intron1 of Egr3 gene showed significant association with schizophrenia (P = 0.0008, Chi2 = 11.156,OR = 1.493). In addition, T-G-C-G haplotype of Egr3 was under-presented in the patients with schizophrenia (P = 0.0073, Chi2 = 7.188, OR = 0.697). However, association between SNPs of Egr2 and schizophrenia was not found. Conclusions: These findings are in consistent with the previous genetic association of Egr3 gene in Japanese cohorts, which could suggest Egr3 as a compelling susceptibility gene in schizophrenia. | ko_KR |
dc.description.sponsorship | Supported by A grant of the Korea health 21 R&D Project, Ministry for
Health, Welfare and Family Affairs, Republic of Korea (A030001) | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.title | The Replication of Egr3 as a Potential Susceptibility Gene for Schizophrenia in Korean Patients with Schizophrenia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김세현 | - |
dc.contributor.AlternativeAuthor | 송주윤 | - |
dc.contributor.AlternativeAuthor | 주은정 | - |
dc.contributor.AlternativeAuthor | 이규영 | - |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 김용식 | - |
dc.citation.journaltitle | BIOLOGICAL PSYCHIATRY | - |
dc.description.tc | 0 | - |
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