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Multi-level comparison of empathy in schizophrenia: An fMRI study of a cartoon task

Cited 49 time in Web of Science Cited 52 time in Scopus
Authors
Lee, Seung Jae; Kang, Do Hyung; Kim, Chi-Won; Gu, Bon Mi; Choi, Chi-Hoon; Lee, Jong-Min; Kwon, Jun Soo; Shin, Na Young; Park, Ji-Young
Issue Date
2010-02-28
Publisher
ELSEVIER IRELAND LTD
Citation
PSYCHIATRY RESEARCH-NEUROIMAGING; Vol.181 2; 121-129
Keywords
EmpathyfMRISocial cognitionSchizophrenia
Abstract
Empathy deficits might play a role in social dysfunction in schizophrenia. However, few studies have investigated the neuroanatomical underpinnings of the subcomponents of empathy in schizophrenia. This study investigated the hemodynamic responses to three subcomponents of empathy in patients with schizophrenia (N=15) and healthy volunteers (N=18), performing an empathy cartoon task during functional magnetic resonance imaging. The experiment used a block design with four conditions: cognitive, emotional, and inhibitory empathy, and physical causality control. Data were analyzed by comparing the blood-oxygen-level-dependent (BOLD) signal activation between the two groups. The cognitive empathy condition activated the right temporal pole to a lesser extent in the patient group than in comparison subjects. in the emotional and inhibitory conditions, the patients showed greater activation in the left insula and in the right middle/inferior frontal cortex, respectively. These findings add to our understanding of the impaired empathy in patients with schizophrenia by identifying a multi-level cortical dysfunction that underlies a deficit in each subcomponent of empathy and highlighting the importance of the fronto-temporal cortical network in ability to empathize. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN
0925-4927
Language
English
URI
http://hdl.handle.net/10371/78492
DOI
https://doi.org/10.1016/j.pscychresns.2009.08.003
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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